Influence of perfluorooctanoic acid on proteomic expression and cell membrane fatty acid of Escherichia coli

被引：33

作者：

Yang, Meng ^{[1
,2
]}

Ye, Jinshao ^{[3
]}

Qin, Huaming ^{[1
,2
]}

Long, Yan ^{[1
,2
]}

Li, Yi ^{[1
,2
]}

机构：

[1] Jinan Univ, Sch Environm, Guangzhou Key Lab Environm Exposure & Hlth, Guangzhou 510632, Guangdong, Peoples R China

[2] Jinan Univ, Guangdong Key Lab Environm Pollut & Hlth, Guangzhou 510632, Guangdong, Peoples R China

[3] Lawrence Berkeley Natl Lab, Joint Genome Inst, Walnut Creek, CA 94598 USA

来源：

ENVIRONMENTAL POLLUTION | 2017年 / 220卷

基金：

中国国家自然科学基金;

关键词：

Resistance mechanism; PFOA; Escherichia coli; iTRAQ; Proteomic analysis; SULFONATE PFOS; HOMEOSTASIS; PROTEASE; FLUIDITY; SUBUNIT; BINDING; GROWTH; LIPIDS;

D O I：

10.1016/j.envpol.2016.09.097

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Perfluorooctanoic acid (PFOA) has received an increasing attention in the agricultural and food industries due to its risk to human health. To facilitate the development of novel biomarkers of Escherichia coli against PFOA through multi-omics technologies, and to reveal the resistance mechanism of E. coil against PFOA at protein levels, the interactions among pollutant stress, protein expression and cell metabolism was investigated by using iTRAQ-based quantitative proteomic analysis. The results revealed that the 63 up-regulated proteins mainly involved in tricarboxylic acid cycle, glyoxylate and dicarboxylate metabolism and fatty acid biosynthesis, whereas, the 69 down-regulated proteins related to oxidative phosphorylation, pyruvate metabolism and the cell cycle-caulobacter pathway, were also associated with the increase of membrane permeability, excessive expenditure of ATP, disruption of fatty acid biosynthesis under PFOA stress. The results provide novel insights into the influence mechanisms of PFOA on fatty acid and protein networks. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：532 / 539

页数：8

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