Cardiometabolic dysregulation and cognitive decline: potential role of depressive symptoms

被引:28
作者
Schmitz, Norbert [1 ,2 ,3 ]
Deschenes, Sonya S. [1 ,2 ]
Burns, Rachel J. [1 ,2 ]
Danna, Sofia M. [4 ]
Franco, Oscar H. [5 ]
Ikram, M. Arfan [5 ]
Kivimaki, Mika [6 ]
Singh-Manoux, Archana [6 ,7 ]
Tiemeier, Henning [8 ,9 ]
机构
[1] McGill Univ, Dept Psychiat, Montreal, PQ, Canada
[2] Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada
[3] Montreal Diabet Res Ctr, Montreal, PQ, Canada
[4] McGill Univ, Dept Epidemiol & Biostat, Montreal, PQ, Canada
[5] Erasmus MC, Univ Med Ctr Rotterdam, Dept Epidemiol, Rotterdam, Netherlands
[6] UCL, Dept Epidemiol & Publ Hlth, London, England
[7] Hop Paul Brousse, INSERM, Ctr Res Epidemiol & Populat Hlth, U1018, Villejuif, France
[8] Erasmus MC, Univ Med Ctr Rotterdam, Dept Psychiat, Dept Epidemiol, Rotterdam, Netherlands
[9] Erasmus MC, Univ Med Ctr Rotterdam, Dept Child & Adolescent Psychiat, Rotterdam, Netherlands
基金
英国医学研究理事会;
关键词
INCREASED RISK; METABOLIC SYNDROME; DEMENTIA; DISEASE; ASSOCIATION; DISORDERS; METAANALYSIS; COMPONENTS; AGE;
D O I
10.1192/bjp.2017.26
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background Previous studies have examined associations of cardiometabolic factors with depression and cognition separately. Aims To determine if depressive symptoms mediate the association between cardiometabolic factors and cognitive decline in two community studies. Method Data for the analyses were drawn from the Rotterdam Study, the Netherlands (n = 2940) and the Whitehall II study, UK (n = 4469). Results Mediation analyses suggested a direct association between cardiometabolic factors and cognitive decline and an indirect association through depression: poorer cardiometabolic status at time 1 was associated with a higher level of depressive symptoms at time 2 (standardised regression coefficient 0.07 and 0.06, respectively), which, in turn, was associated with greater cognitive decline between time 2 and time 3 (standardised regression coefficient of -0.15 and -0.41, respectively). Conclusions Evidence from two independent cohort studies suggest an association between cardiometabolic dysregulation and cognitive decline and that depressive symptoms tend to precede this decline.
引用
收藏
页码:96 / 102
页数:7
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