How chemokines invite leukocytes to dance

被引：251

作者：

Thelen, Marcus ^{[1
]}

Stein, Jens V. ^{[2
]}

机构：

[1] Inst Biomed Res, CH-6500 Bellinzona, Switzerland

[2] Univ Bern, Theodor Kocher Inst, CH-3012 Bern, Switzerland

来源：

NATURE IMMUNOLOGY | 2008年 / 9卷 / 09期

基金：

瑞士国家科学基金会;

关键词：

D O I：

10.1038/ni.f.207

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A prominent activity of the chemokine system is the regulation of leukocyte trafficking. Here we summarize recent findings on the initial steps in chemokine receptor-induced signal transduction in leukocytes. In particular, we discuss the potential influences of the formation of oligomers of ligand and receptor and of coupling between chemokine signals and regulators of the cytoskeleton, such as small GTPases.

引用

收藏

页码：953 / 959

页数：7

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