In situ quantitative measurement of concentration profiles in a microreactor with submicron resolution using multiplex CARS microscopy

被引：38

作者：

Schafer, Dawn ^{[2
]}

Squier, Jeff A. ^{[2
]}

van Maarseveen, Jan ^{[3
]}

Bonn, Daniel ^{[3
]}

Bonn, Mischa ^{[1
]}

Mueller, Michiel ^{[3
]}

机构：

[1] FOM, Inst Atom & Mol Phys, NL-1098 SJ Amsterdam, Netherlands

[2] Colorado Sch Mines, Dept Phys, Golden, CO 80401 USA

[3] Univ Amsterdam, NL-1018 WS Amsterdam, Netherlands

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 35期

关键词：

D O I：

10.1021/ja804158n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In situ quantitative imaging of concentration profiles of reactants and products inside a microfluidic reactor is achieved, with submicron spatial resolution with similar to mM sensitivity and on similar to ms time scales, for a given position. The label-free approach relies on quantitative vibrational spectroscopy, using Coherent Anti-Stokes Raman scattering microscopy in a spectrally resolved fashion, and is demonstrated on an elementary acid-base reaction.

引用

页码：11592 / +

页数：3

共 15 条

[1] Raman microspectroscopy/imaging study on phase-vanishing processes of fluorous biphase systems in microchannel-microheater chips [J].

Araki, Takeshi ;

Ueno, Kousei ;

Misawa, Hiroaki ;

Kitamura, Noboru .

ANALYTICAL SCIENCES, 2006, 22 (10) :1283-1289

[2] Raman spectroscopic monitoring of droplet polymerization in a microfluidic device [J].

Barnes, Susan E. ;

Cygan, Zuzanna T. ;

Yates, Jesse K. ;

Beers, Kathryn L. ;

Amis, Eric J. .

ANALYST, 2006, 131 (09) :1027-1033

[3] Coherent anti-Stokes Raman scattering microscopy: Instrumentation, theory, and applications [J].

Cheng, JX ;

Xie, XS .

JOURNAL OF PHYSICAL CHEMISTRY B, 2004, 108 (03) :827-840

[4] Control and detection of chemical reactions in microfluidic systems [J].

deMello, Andrew J. .

NATURE, 2006, 442 (7101) :394-402

[5] Chemically-selective imaging of brain structures with CARS microscopy [J].

Evans, Conor L. ;

Xu, Xiaoyin ;

Kesari, Santosh ;

Xie, X. Sunney ;

Wong, Stephen T. C. ;

Young, Geoffrey S. .

OPTICS EXPRESS, 2007, 15 (19) :12076-12087

[6] Monitoring of chemical reactions within microreactors using an inverted Raman microscopic spectrometer [J].

Fletcher, PDI ;

Haswell, SJ ;

Zhang, XL .

ELECTROPHORESIS, 2003, 24 (18) :3239-3245

[7] Applicability of laser-induced Raman microscopy for in situ monitoring of imine formation in a glass microfluidic chip [J].

Lee, M ;

Lee, JP ;

Rhee, H ;

Choo, J ;

Chai, YG ;

Lee, EK .

JOURNAL OF RAMAN SPECTROSCOPY, 2003, 34 (10) :737-742

[8] Label-free coherent anti-stokes Raman scattering imaging of coexisting lipid domains in single bilayers [J].

Li, Li ;

Cheng, Ji-Xin .

JOURNAL OF PHYSICAL CHEMISTRY B, 2008, 112 (06) :1576-1579

[9] Quantitative spatial mapping of mixing in microfluidic systems [J].

Magennis, SW ;

Graham, EM ;

Jones, AC .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (40) :6512-6516

[10] Analysis of passive mixing behavior in a poly(dimethylsiloxane) microfluidic channel using confocal fluorescence and Raman microscopy [J].

Park, T ;

Lee, M ;

Choo, J ;

Kim, YS ;

Lee, EK ;

Kim, DJ ;

Lee, SH .

APPLIED SPECTROSCOPY, 2004, 58 (10) :1172-1179

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