Incidence and time trends of brain metastases admissions among breast cancer patients in Sweden

被引：83

作者：

Frisk, G. ^{[1
]}

Svensson, T. ^{[1
]}

Backlund, L. M. ^{[2
]}

Lidbrink, E. ^{[3
]}

Blomqvist, P. ^{[1
]}

Smedby, K. E. ^{[1
]}

机构：

[1] Karolinska Inst Solna, Clin Epidemiol Unit, Dept Med Solna, S-17176 Stockholm, Sweden

[2] Karolinska Inst Solna, Unit Expt Cardiovasc Res, Dept Med Solna, S-17176 Stockholm, Sweden

[3] Karolinska Inst, Karolinska Univ Hosp Solna, Dept Oncol Pathol, S-17176 Stockholm, Sweden

来源：

BRITISH JOURNAL OF CANCER | 2012年 / 106卷 / 11期

关键词：

breast cancer; brain metastases; incidence; EPIDEMIOLOGY; CARCINOMA; SYSTEM; RISK;

D O I：

10.1038/bjc.2012.163

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUND: While treatment for breast cancer has been refined and overall survival has improved, there is concern that the incidence of brain metastases has increased. METHODS: We identified patients in Sweden with incident breast cancer 1998-2006 in the National Cancer Register, and matched these to the National Patient Register to obtain information on hospital admissions for distant metastases. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed with Cox regression as estimates of relative risk. RESULTS: Among 50 528 breast cancer patients, 696 (1.4%) were admitted with brain metastases during median 3.5 years of follow-up. Admissions for other metastases were found in 3470 (6.9%) patients. Compared with the period 1998-2000, patients diagnosed with breast cancer 2004-2006 were at a 44% increased risk of being admitted with brain metastases (HR 1.44, 95% CI 1.13-1.85). CONCLUSION: The incidence of admissions with brain metastases in breast cancer patients was increasing in the mid-2000s in Sweden. These findings support a true increase in incidence of brain metastases among breast cancer patients. British Journal of Cancer (2012) 106, 1850-1853. doi:10.1038/bjc.2012.163 www.bjcancer.com Published online 24 April 2012 (C) 2012 Cancer Research UK

引用

页码：1850 / 1853

页数：4

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