Premenopausal serum sex hormone levels in relation to breast cancer risk, overall and by hormone receptor status-Results from the EPIC cohort

被引：63

作者：

Kaaks, Rudolf ^{[1
]}

Tikk, Kaja ^{[1
]}

Sookthai, Disorn ^{[1
]}

Schock, Helena ^{[1
]}

Johnson, Theron ^{[1
]}

Tjonneland, Anne ^{[2
]}

Olsen, Anja ^{[2
]}

Overvad, Kim ^{[3
]}

Clavel-Chapelon, Francoise ^{[4
,5
,6
]}

Dossus, Laure ^{[4
,5
,6
]}

Baglietto, Laura ^{[7
,8
]}

Rinaldi, Sabina ^{[9
]}

Chajes, Veronique ^{[9
]}

Romieu, Isabelle ^{[9
]}

Boeing, Heiner ^{[10
]}

Schuetze, Madlen ^{[10
]}

Trichopoulou, Antonia ^{[11
,12
]}

Lagiou, Pagona ^{[11
,13
,14
]}

Trichopoulos, Dimitrios ^{[12
,13
,14
]}

Palli, Domenico ^{[15
]}

Sieri, Sabina ^{[16
]}

Tumino, Rosario ^{[17
,18
]}

Ricceri, Fulvio ^{[19
,20
]}

Mattiello, Amalia ^{[21
]}

Buckland, Genevieve ^{[22
]}

Ramon Quiros, Jose ^{[23
]}

Sanchez, Maria-Jose ^{[24
,25
,26
]}

Amiano, Pilar ^{[26
,27
]}

Chirlaque, Maria-Dolores ^{[26
,28
]}

Barricarte, Aurelio ^{[26
,29
]}

Bas Bueno-de-Mesquita, H. ^{[30
,31
,32
]}

van Gils, Carla H. ^{[33
]}

Peeters, Petra H. ^{[32
,33
]}

Andersson, Anne ^{[34
]}

Sund, Malin ^{[35
]}

Weiderpass, Elisabete ^{[36
,37
,38
,39
]}

Khaw, Kay-Tee ^{[40
]}

Wareham, Nick ^{[41
]}

Key, Timothy J. ^{[42
]}

Travis, Ruth C. ^{[42
]}

Merritt, Melissa A. ^{[32
]}

Gunter, Marc J. ^{[32
]}

Riboli, Elio ^{[32
]}

Lukanova, Annekatrin ^{[1
,43
]}

机构：

[1] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[2] Danish Canc Soc Res Ctr, Copenhagen, Denmark

[3] Aarhus Univ, Dept Publ Hlth, Epidemiol Sect, Aarhus, Denmark

[4] Ctr Res Epidemiol & Populat Hlth CESP, INSERM, U1018, Nutr Hormones & Womens Hlth Team, F-94805 Villejuif, France

[5] Univ Paris 11, UMRS 1018, F-94805 Villejuif, France

[6] IGR, F-94805 Villejuif, France

[7] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia

[8] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia

[9] Int Agcy Res Canc, Sect Nutr & Metab, F-69372 Lyon, France

[10] German Inst Human Nutr DIfE Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[11] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece

[12] Hellen Hlth Fdn, Athens, Greece

[13] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[14] Acad Athens, Bur Epidemiol Res, Athens, Greece

[15] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[16] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[17] Civic MP Arezzo Hosp ASP, Canc Registry, Ragusa, Italy

[18] Civic MP Arezzo Hosp ASP, Histopathol Unit, Ragusa, Italy

[19] Human Genet Fdn HuGeF, Turin, Italy

[20] Ordine Mauriziano Hosp, Dept Hosp Med Directorate, Turin, Italy

[21] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[22] Catalan Inst Oncol ICO IDIBELL, Unit Nutr Environm & Canc, Canc Epidemiol Res Programme, Barcelona, Spain

[23] Publ Hlth Directorate, Asturias, Spain

[24] Andalusian Sch Publ Hlth, Granada, Spain

[25] Inst Invest Biosanitario Granada Granada Bs, Granada, Spain

[26] CIBERESP, Consortium Biomed Res Epidemiol & Publ Hlth, Madrid, Spain

[27] Basque Reg Hlth Dept, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[28] Murcia Reg Hlth Author, Dept Epidemiol, Murcia, Spain

[29] Navarre Publ Hlth Inst, Pamplona, Spain

[30] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[31] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[32] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[33] Univ Med Ctr, Dept Epidemiol, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[34] Umea Univ, Dept Radiat Sci, Umea, Sweden

[35] Umea Univ Hosp, Dept Surg, S-90185 Umea, Sweden

[36] Univ Tromso, Dept Community Med, Fac Hlth Sci, Tromso, Norway

[37] Canc Registry Norway, Dept Res, Oslo, Norway

[38] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[39] Samfundet Folkhalsan, Dept Genet Epidemiol, Helsinki, Finland

[40] Univ Cambridge, Sch Clin Med, Cambridge, England

[41] MRC, Epidemiol Unit, Cambridge, England

[42] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[43] Umea Univ, Dept Med Biosci, Umea, Sweden

来源：

INTERNATIONAL JOURNAL OF CANCER | 2014年 / 134卷 / 08期

关键词：

breast cancer; estrogen receptor; sex hormones; prospective cohort; EPIC; FEMALE NOBLE RATS; POSTMENOPAUSAL WOMEN; ANDROGEN RECEPTOR; FREE TESTOSTERONE; STEROID-HORMONES; ESTRADIOL; ESTROGEN; GROWTH; REPRODUCIBILITY; CARCINOGENESIS;

D O I：

10.1002/ijc.28528

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Results from prospective studies on premenopausal serum hormone levels in relation to breast cancer risk have been inconclusive, especially with regard to tumor subtypes. Using a case-control study nested within the prospective European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (801 breast cancer cases and 1,132 matched control subjects), we analyzed the relationships of prediagnostic serum estradiol, free estradiol, progesterone, testosterone, free testosterone and sex hormone-binding globulin (SHBG) levels with the risk of breast cancer by estrogen and progesterone receptor-positive and -negative breast tumors and by age at diagnoses. Higher prediagnostic serum levels of testosterone and free testosterone were associated with an increased overall risk of breast cancer [ORQ4-Q1=1.56 (95% CI 1.15-2.13), p(trend)=0.02 for testosterone and ORQ4-Q1=1.33 (95% CI 0.99-1.79), p(trend)=0.04 for free testosterone], but no significant risk association was observed for estradiol, free estradiol, progesterone and SHBG. Tests for heterogeneity between receptor-positive and -negative tumors were not significant. When analysis were stratified by age at tumor diagnosis, the odds ratios observed for estradiol were stronger and borderline significant for breast cancer diagnosed at age less than 50 [ORQ4-Q1=1.32 (95% CI 0.87-2.01), p(trend)=0.05] compared to breast cancer diagnosed at age 50 or above [ORQ4-Q1=0.94 (95% CI 0.60-1.47), p(trend)=0.34, p(het)=0.04]. In conclusion, our data indicate that higher premenopausal circulating testosterone levels are associated with an increased risk of developing breast cancer, but do not show a significant association of estradiol or progesterone with breast cancer risk, overall, by menstrual cycle phase or by tumor receptor status, although a possible risk increase with higher estradiol levels for tumors diagnosed before age 50 was seen.

引用

页码：1947 / 1957

页数：11

共 45 条

[1]

[Anonymous], 2008, Modern epidemiology

[2] Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies [J].

Beral, V. ;

Bull, D. ;

Pirie, K. ;

Reeves, G. ;

Peto, R. ;

Skegg, D. ;

LaVecchia, C. ;

Magnusson, C. ;

Pike, M. C. ;

Thomas, D. ;

Hamajima, N. ;

Hirose, K. ;

Tajima, K. ;

Rohan, T. ;

Friedenreich, C. M. ;

Calle, E. E. ;

Gapstur, S. M. ;

Patel, A. V. ;

Coates, R. J. ;

Liff, J. M. ;

Talamini, R. ;

Chantarakul, N. ;

Koetsawang, S. ;

Rachawat, D. ;

Marcou, Y. ;

Kakouri, E. ;

Duffy, S. W. ;

Morabia, A. ;

Schuman, L. ;

Stewart, W. ;

Szklo, M. ;

Coogan, P. F. ;

Palmer, J. R. ;

Rosenberg, L. ;

Band, P. ;

Coldman, A. J. ;

Gallagher, R. P. ;

Hislop, T. G. ;

Yang, P. ;

Cummings, S. R. ;

Canfell, K. ;

Sitas, F. ;

Chao, P. ;

Lissowska, J. ;

Horn-Ross, P. L. ;

John, E. M. ;

Kolonel, L. M. ;

Nomura, A. M. Y. ;

Ghiasvand, R. ;

Hu, J. .

LANCET ONCOLOGY, 2012, 13 (11) :1141-1151

[3]

Beral V, 1997, LANCET, V350, P1047, DOI 10.1016/S0140-6736(97)08233-0

[4] Follow-up procedures in EPIC-Germany - Data quality aspects [J].

Bergmann, MM ;

Bussas, U ;

Boeing, H .

ANNALS OF NUTRITION AND METABOLISM, 1999, 43 (04) :225-234

[5] Diet and cancer - The European prospective investigation into cancer and nutrition [J].

Bingham, S ;

Riboli, E .

NATURE REVIEWS CANCER, 2004, 4 (03) :206-215

[6] A review of hormonal changes during the menopausal transition: focus on findings from the Melbourne Women's Midlife Health Project [J].

Burger, H. G. ;

Hale, G. E. ;

Robertson, D. M. ;

Dennerstein, L. .

HUMAN REPRODUCTION UPDATE, 2007, 13 (06) :559-565

[7] Androgen levels in adult females: Changes with age, menopause, and oophorectomy [J].

Davison, SL ;

Bell, R ;

Donath, S ;

Montalto, JG ;

Davis, SR .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (07) :3847-3853

[8] Androgens and androgen receptors in breast cancer [J].

Diaz-Chico, B. Nicolas ;

German Rodriguez, F. ;

Gonzalez, Ana ;

Ramirez, Raquel ;

Bilbao, Cristina ;

Cabrera de Leon, A. ;

Aguirre Jaime, A. ;

Chirino, Ricardo ;

Navarro, Domingo ;

Diaz-Chico, Juan C. .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2007, 105 (1-5) :1-15

[9]

Dickson R B, 2000, J Natl Cancer Inst Monogr, P135

[10]

Dimitrakakis C, 2002, FERTIL STERIL, V77, pS26

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