Planar Cell Polarity Signaling: From Fly Development to Human Disease

被引:424
作者
Simons, Matias [1 ]
Mlodzik, Marek [1 ]
机构
[1] Mt Sinai Sch Med, Dept Dev & Regenerat Biol, New York, NY 10029 USA
关键词
cell polarity; drosophila; organ patterning; frizzled-pcp signaling; ciliopathies;
D O I
10.1146/annurev.genet.42.110807.091432
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Most, if not all, cell types and tissues display several aspects of polarization. In addition to the ubiquitous epithelial cell polarity along the apical-basolateral axis, many epithelial tissues and organs are also polarized within the plane of the epithelium. This is generally referred to as planar cell polarity PCP; or historically, tissue polarity. Genetic screens in Drosophila pioneered the discovery of core PCP factors, and subsequent work in vertebrates has established that the respective pathways are evolutionarily conserved. PCP is not restricted only to epithelial tissues but is also found in mesenchymal cells, where it can regulate cell migration and cell intercalation. Moreover, particularly in vertebrate the conserved core PCP signaling factors have recently been found to be associated with the orientation or formation of cilia. This review discusses new developments in the molecular understanding of PCP establishment in Drosophila and vertebrates; these developments are integrated with new evidence that links PCP signaling to human disease.
引用
收藏
页码:517 / 540
页数:24
相关论文
共 50 条
[31]   Polycystic Kidney Disease, Cilia, and Planar Polarity [J].
Menezes, Luis F. ;
Germino, Gregory G. .
PRIMARY CILIA, 2009, 94 :273-+
[32]   The role of the hedgehog/patched signaling pathway in epithelial stem cell proliferation: From fly to human [J].
Parisi M.J. ;
Lin H. .
Cell Research, 1998, 8 (1) :15-21
[33]   The role of the hedgehog/patched signaling pathway in epithelial stem cell proliferation: from fly to human [J].
PARISI MICHAEL J ;
HAIFAN LIN (Depariment of Cell Biology .
Cell Research, 1998, (01) :15-21
[34]   Mitotic internalization of planar cell polarity proteins preserves tissue polarity [J].
Devenport, Danelle ;
Oristian, Daniel ;
Heller, Evan ;
Fuchs, Elaine .
NATURE CELL BIOLOGY, 2011, 13 (08) :893-U418
[35]   Control of photoreceptor cell morphology, planar polarity and epithelial integrity during Drosophila eye development [J].
Pickup, AT ;
Lamka, ML ;
Sun, Q ;
Yip, MLR ;
Lipshitz, HD .
DEVELOPMENT, 2002, 129 (09) :2247-2258
[36]   Regulation of Planar Cell Polarity by Smurf Ubiquitin Ligases [J].
Narimatsu, Masahiro ;
Bose, Rohit ;
Pye, Melanie ;
Zhang, Liang ;
Miller, Bryan ;
Ching, Peter ;
Sakuma, Rui ;
Luga, Valbona ;
Roncari, Luba ;
Attisano, Liliana ;
Wrana, Jeffrey L. .
CELL, 2009, 137 (02) :295-307
[37]   The multiple links between cilia and planar cell polarity [J].
Ezan, Jerome ;
Montcouquiol, Mireille .
M S-MEDECINE SCIENCES, 2014, 30 (11) :1004-1010
[38]   Propagation of Dachsous-Fat Planar Cell Polarity [J].
Ambegaonkar, Abhijit A. ;
Pan, Guohui ;
Mani, Madhav ;
Feng, Yongqiang ;
Irvine, Kenneth D. .
CURRENT BIOLOGY, 2012, 22 (14) :1302-1308
[39]   The Formin DAAM Functions as Molecular Effector of the Planar Cell Polarity Pathway during Axonal Development in Drosophila [J].
Gombos, Rita ;
Migh, Ede ;
Antal, Otilia ;
Mukherjee, Anindita ;
Jenny, Andreas ;
Mihaly, Jozsef .
JOURNAL OF NEUROSCIENCE, 2015, 35 (28) :10154-10167
[40]   Planar cell polarity: intracellular asymmetry and supracellular gradients of Frizzled [J].
Casal, Jose ;
Storer, Freya ;
Lawrence, Peter A. .
OPEN BIOLOGY, 2023, 13 (06)