BCG vaccine: a hope to control COVID-19 pandemic amid crisis

被引：18

作者：

Malik, Yashpal Singh ^{[1
]}

Ansari, Mohd Ikram ^{[1
]}

Ganesh, Balasubramanian ^{[2
]}

Sircar, Shubhankar ^{[1
]}

Bhat, Sudipta ^{[1
]}

Pande, Tripti ^{[1
]}

Vinodhkumar, O. R. ^{[3
]}

Kumar, Prashant ^{[4
]}

Yatoo, Mohd Iqbal ^{[5
]}

Tiwari, Ruchi ^{[6
]}

Touil, Nadia ^{[7
]}

Patel, Shailesh Kumar ^{[8
]}

Pathak, Mamta ^{[8
]}

Sharun, Khan ^{[9
]}

Dhama, Kuldeep ^{[8
]}

机构：

[1] ICAR Indian Vet Res Inst, Div Biol Standardizat, Bareilly, Uttar Pradesh, India

[2] Indian Council Med Res, ICMR Natl Inst Epidemiol, Dept Hlth Res DHR, Lab Div,Govt India,Minist Hlth & Family Welf, Chennai, Tamil Nadu, India

[3] ICAR Indian Vet Res Inst, Div Epidemiol, Bareilly, Uttar Pradesh, India

[4] Amity Univ, Amity Inst Virol & Immunol, J-3 Block, Noida, Uttar Pradesh, India

[5] Sher E Kashmir Univ Agr Sci & Technol Kashmir, Fac Vet Sci & Anim Husb, Div Vet Clin Complex, Srinagar, Jammu & Kashmir, India

[6] Pandit Deen Dayal Upadhayay Pashu Chikitsa Vigyan, Coll Vet Sci, Dept Vet Microbiol & Immunol, Mathura, India

[7] Hop Mil Instruct Med V, Lab Rech & Biosecurite, Rabat, Morocco

[8] ICAR Indian Vet Res Inst, Div Pathol, Bareilly, Uttar Pradesh, India

[9] ICAR Indian Vet Res Inst, Div Surg, Bareilly, Uttar Pradesh, India

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2020年 / 16卷 / 12期

关键词：

COVID-19; sars-CoV-2; tuberculosis; bcg vaccine; immune response; cross-reactivity; trained immunity; BACILLUS-CALMETTE-GUERIN; BLADDER-CANCER; PROTECTION; IMMUNITY; INNATE; IMMUNOTHERAPY; TUBERCULOSIS; METAANALYSIS; PERSPECTIVE; THERAPY;

D O I：

10.1080/21645515.2020.1818522

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

COVID-19 caused by the virus SARS-CoV-2 has gripped essentially all countries in the world, and has infected millions and killed hundreds of thousands of people. Several innovative approaches are in development to restrain the spread of SARS-CoV-2. In particular, BCG, a vaccine against tuberculosis (TB), is being considered as an alternative therapeutic modality. BCG vaccine is known to induce both humoral and adaptive immunities, thereby activating both nonspecific and cross-reactive immune responses in the host, which combined could effectively resist other pathogens including SARS-CoV-2. Notably, some studies have revealed that SARS-CoV-2 infectivity, case positivity, and mortality rate have been higher in countries that have not adopted BCG vaccination than in countries that have done so. This review presents an overview of the concepts underlying BCG vaccination and its nonspecific immuological effects and protection, resulting in 'trained immunity' and potential utility for resisting COVID-19.

引用

页码：2954 / 2962

页数：9

共 80 条

[71] Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430 [J].

Warren, Travis K. ;

Wells, Jay ;

Panchal, Rekha G. ;

Stuthman, Kelly S. ;

Garza, Nicole L. ;

Van Tongeren, Sean A. ;

Dong, Lian ;

Retterer, Cary J. ;

Eaton, Brett P. ;

Pegoraro, Gianluca ;

Honnold, Shelley ;

Bantia, Shanta ;

Kotian, Pravin ;

Chen, Xilin ;

Taubenheim, Brian R. ;

Welch, Lisa S. ;

Minning, Dena M. ;

Babu, Yarlagadda S. ;

Sheridan, William P. ;

Bavari, Sina .

NATURE, 2014, 508 (7496) :402-+

[72] COVID-19: what has been learned and to be learned about the novel coronavirus disease [J].

Yi, Ye ;

Lagniton, Philip N. P. ;

Ye, Sen ;

Li, Enqin ;

Xu, Ren-He .

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2020, 16 (10) :1753-1766

[73] Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore [J].

Young, Barnaby Edward ;

Ong, Sean Wei Xiang ;

Kalimuddin, Shirin ;

Low, Jenny G. ;

Tan, Seow Yen ;

Loh, Jiashen ;

Ng, Oon-Tek ;

Marimuthu, Kalisvar ;

Ang, Li Wei ;

Mak, Tze Minn ;

Lau, Sok Kiang ;

Anderson, Danielle E. ;

Chan, Kian Sing ;

Tan, Thean Yen ;

Ng, Tong Yong ;

Cui, Lin ;

Said, Zubaidah ;

Kurupatham, Lalitha ;

Chen, Mark I-Cheng ;

Chan, Monica ;

Vasoo, Shawn ;

Wang, Lin-Fa ;

Tan, Boon Huan ;

Lin, Raymond Tzer Pin ;

Lee, Vernon Jian Ming ;

Leo, Yee-Sin ;

Lye, David Chien .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (15) :1488-1494

[74] The Novel Dual GLP-1/GIP Receptor Agonist DA-CH5 Is Superior to Single GLP-1 Receptor Agonists in the MPTP Model of Parkinson?s Disease [J].

Zhang, Lingyu ;

Zhang, Liping ;

Li, Yanwei ;

Li, Lin ;

Melchiorsen, Josefine Ulrikke ;

Rosenkilde, Mette ;

Holscher, Christian .

JOURNAL OF PARKINSONS DISEASE, 2020, 10 (02) :523-542

[75]

Zhang Tony Y, 2020, Med Drug Discov, V5, P100036, DOI 10.1016/j.medidd.2020.100036

[76] A Genomic Perspective on the Origin and Emergence of SARS-CoV-2 [J].

Zhang, Yong-Zhen ;

Holmes, Edward C. .

CELL, 2020, 181 (02) :223-227

[77] Stem Cell-Based Therapy for Coronavirus Disease 2019 [J].

Zhao, Robert Chunhua .

STEM CELLS AND DEVELOPMENT, 2020, 29 (11) :679-681

[78] Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial [J].

Zhu, Feng-Cai ;

Li, Yu-Hua ;

Guan, Xu-Hua ;

Hou, Li-Hua ;

Wang, Wen-Juan ;

Li, Jing-Xin ;

Wu, Shi-Po ;

Wang, Bu-Sen ;

Wang, Zhao ;

Wang, Lei ;

Jia, Si-Yue ;

Jiang, Hu-Dachuan ;

Wang, Ling ;

Jiang, Tao ;

Hu, Yi ;

Gou, Jin-Bo ;

Xu, Sha-Bei ;

Xu, Jun-Jie ;

Wang, Xue-Wen ;

Wang, Wei ;

Chen, Wei .

LANCET, 2020, 395 (10240) :1845-1854

[79]

Zou LR, 2020, NEW ENGL J MED, V382, P1177, DOI [10.1056/NEJMc2001737, 10.1148/radiol.2020200463]

[80] The BCG World Atlas: A Database of Global BCG Vaccination Policies and Practices [J].

Zwerling, Alice ;

Behr, Marcel A. ;

Verma, Aman ;

Brewer, Timothy F. ;

Menzies, Dick ;

Pai, Madhukar .

PLOS MEDICINE, 2011, 8 (03)

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