BCG vaccine: a hope to control COVID-19 pandemic amid crisis

被引：18

作者：

Malik, Yashpal Singh ^{[1
]}

Ansari, Mohd Ikram ^{[1
]}

Ganesh, Balasubramanian ^{[2
]}

Sircar, Shubhankar ^{[1
]}

Bhat, Sudipta ^{[1
]}

Pande, Tripti ^{[1
]}

Vinodhkumar, O. R. ^{[3
]}

Kumar, Prashant ^{[4
]}

Yatoo, Mohd Iqbal ^{[5
]}

Tiwari, Ruchi ^{[6
]}

Touil, Nadia ^{[7
]}

Patel, Shailesh Kumar ^{[8
]}

Pathak, Mamta ^{[8
]}

Sharun, Khan ^{[9
]}

Dhama, Kuldeep ^{[8
]}

机构：

[1] ICAR Indian Vet Res Inst, Div Biol Standardizat, Bareilly, Uttar Pradesh, India

[2] Indian Council Med Res, ICMR Natl Inst Epidemiol, Dept Hlth Res DHR, Lab Div,Govt India,Minist Hlth & Family Welf, Chennai, Tamil Nadu, India

[3] ICAR Indian Vet Res Inst, Div Epidemiol, Bareilly, Uttar Pradesh, India

[4] Amity Univ, Amity Inst Virol & Immunol, J-3 Block, Noida, Uttar Pradesh, India

[5] Sher E Kashmir Univ Agr Sci & Technol Kashmir, Fac Vet Sci & Anim Husb, Div Vet Clin Complex, Srinagar, Jammu & Kashmir, India

[6] Pandit Deen Dayal Upadhayay Pashu Chikitsa Vigyan, Coll Vet Sci, Dept Vet Microbiol & Immunol, Mathura, India

[7] Hop Mil Instruct Med V, Lab Rech & Biosecurite, Rabat, Morocco

[8] ICAR Indian Vet Res Inst, Div Pathol, Bareilly, Uttar Pradesh, India

[9] ICAR Indian Vet Res Inst, Div Surg, Bareilly, Uttar Pradesh, India

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2020年 / 16卷 / 12期

关键词：

COVID-19; sars-CoV-2; tuberculosis; bcg vaccine; immune response; cross-reactivity; trained immunity; BACILLUS-CALMETTE-GUERIN; BLADDER-CANCER; PROTECTION; IMMUNITY; INNATE; IMMUNOTHERAPY; TUBERCULOSIS; METAANALYSIS; PERSPECTIVE; THERAPY;

D O I：

10.1080/21645515.2020.1818522

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

COVID-19 caused by the virus SARS-CoV-2 has gripped essentially all countries in the world, and has infected millions and killed hundreds of thousands of people. Several innovative approaches are in development to restrain the spread of SARS-CoV-2. In particular, BCG, a vaccine against tuberculosis (TB), is being considered as an alternative therapeutic modality. BCG vaccine is known to induce both humoral and adaptive immunities, thereby activating both nonspecific and cross-reactive immune responses in the host, which combined could effectively resist other pathogens including SARS-CoV-2. Notably, some studies have revealed that SARS-CoV-2 infectivity, case positivity, and mortality rate have been higher in countries that have not adopted BCG vaccination than in countries that have done so. This review presents an overview of the concepts underlying BCG vaccination and its nonspecific immuological effects and protection, resulting in 'trained immunity' and potential utility for resisting COVID-19.

引用

页码：2954 / 2962

页数：9

共 80 条

[61] Immunogenicity of a DNA vaccine candidate for COVID-19 [J].

Smith, Trevor R. F. ;

Patel, Ami ;

Ramos, Stephanie ;

Elwood, Dustin ;

Zhu, Xizhou ;

Yan, Jian ;

Gary, Ebony N. ;

Walker, Susanne N. ;

Schultheis, Katherine ;

Purwar, Mansi ;

Xu, Ziyang ;

Walters, Jewell ;

Bhojnagarwala, Pratik ;

Yang, Maria ;

Chokkalingam, Neethu ;

Pezzoli, Patrick ;

Parzych, Elizabeth ;

Reuschel, Emma L. ;

Doan, Arthur ;

Tursi, Nicholas ;

Vasquez, Miguel ;

Choi, Jihae ;

Tello-Ruiz, Edgar ;

Maricic, Igor ;

Bah, Mamadou A. ;

Wu, Yuanhan ;

Amante, Dinah ;

Park, Daniel H. ;

Dia, Yaya ;

Ali, Ali Raza ;

Zaidi, Faraz, I ;

Generotti, Alison ;

Kim, Kevin Y. ;

Herring, Timothy A. ;

Reeder, Sophia ;

Andrade, Viviane M. ;

Buttigieg, Karen ;

Zhao, Gan ;

Wu, Jiun-Ming ;

Li, Dan ;

Bao, Linlin ;

Liu, Jiangning ;

Deng, Wei ;

Qin, Chuan ;

Brown, Ami Shah ;

Khoshnejad, Makan ;

Wang, Nianshuang ;

Chu, Jacqueline ;

Wrapp, Daniel ;

McLellan, Jason S. .

NATURE COMMUNICATIONS, 2020, 11 (01)

[62] Potential population level impact on tuberculosis incidence of using an mRNA expression signature correlate-of-risk test to target tuberculosis preventive therapy [J].

Sumner, Tom ;

Scriba, Thomas J. ;

Penn-Nicholson, Adam ;

Hatherill, Mark ;

White, Richard G. .

SCIENTIFIC REPORTS, 2019, 9 (1) :11126

[63] The Humoral Immune Response to BCG Vaccination [J].

Tanner, Rachel ;

Villarreal-Ramos, Bernardo ;

Vordermeier, H. Martin ;

McShane, Helen .

FRONTIERS IN IMMUNOLOGY, 2019, 10

[64] New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia [J].

Tarancon, Raquel ;

Dominguez-Andres, Jorge ;

Uranga, Santiago ;

Ferreira, Anaisa, V ;

Groh, Laszlo A. ;

Domenech, Mirian ;

Gonzalez-Camacho, Fernando ;

Riksen, Niels P. ;

Aguilo, Nacho ;

Yuste, Jose ;

Martin, Carlos ;

Netea, Mihai G. .

PLOS PATHOGENS, 2020, 16 (04)

[65] Effect of BCG vaccination on childhood tuberculous meningitis and miliarytuberculosis worldwide: a meta-analysis and assessment of cost-effectiveness [J].

Trunz, BB ;

Fine, PEM ;

Dye, C .

LANCET, 2006, 367 (9517) :1173-1180

[66] Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome? [J].

Tsang, John S. ;

Dobano, Carlota ;

VanDamme, Pierre ;

Moncunill, Gemma ;

Marchant, Arnaud ;

Ben Othman, Rym ;

Sadarangani, Manish ;

Koff, Wayne C. ;

Kollmann, Tobias R. .

TRENDS IN IMMUNOLOGY, 2020, 41 (06) :457-465

[67]

Udani P. M., 1994, Indian Journal of Pediatrics, V61, P451, DOI 10.1007/BF02751703

[68] Reassessing therapeutic antibodies for neglected and tropical diseases [J].

van Huijsduijnen, Rob Hooft ;

Kojima, Somei ;

Carter, Dee ;

Okabe, Hisafumi ;

Sato, Akihide ;

Akahata, Wataru ;

Wells, Timothy N. C. ;

Katsuno, Kei .

PLOS NEGLECTED TROPICAL DISEASES, 2020, 14 (01)

[69] Pathogens use carbohydrates to escape immunity induced by dendritic cells [J].

van Kooyk, Y ;

Engering, A ;

Lekkerkerker, AN ;

Ludwig, IS ;

Geijtenbeek, TB .

CURRENT OPINION IN IMMUNOLOGY, 2004, 16 (04) :488-493

[70]

VANTWOUT JW, 1992, SCAND J IMMUNOL, V36, P713

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