The effect of organotin compounds on the permeability of model biological membranes

被引：0
|
作者：
Cullen, WR
Herring, FG
Nwata, BU
机构：
来源：
APPLIED ORGANOMETALLIC CHEMISTRY | 1997年 / 11卷 / 05期
关键词：
efflux; liposomes; dimethylarsinic acid; membrane modification; egg phosphatidylcholine; bilayer; tributyltin chloride; monobutyltin trichloride; facilitated diffusion; NMR;
D O I：
10.1002/(SICI)1099-0739(199705)11:5<369::AID-AOC585>3.3.CO;2-F
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The efflux of dimethylarsinic acid (DMA) from liposomes formed from egg phosphatidylcholine (EPC) is increased when tributyltin chloride (TBT) is added to the extraliposomal compartment; however the addition of monobutyltin trichloride (MBT) slows down the efflux. When the liposomes are prepared from EPC and organotin compounds, different mechanisms for DMA efflux seem to operate: TBT-EPC liposomes show a mixture of facilitated and passive diffusion; MBT-EPC liposomes show only passive diffusion. The facilitated diffusion of DMA(-) seems to be stopped by the addition of TBT to the extraliposomal compartment. (C) 1997 by John Wiley & Sons, Ltd.
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页码：369 / 379
页数：11
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