Gadolinium nanoparticles as diagnostic and therapeutic agents: Their delivery systems in magnetic resonance imaging and neutron capture therapy

被引：102

作者：

Narmani, Asghar ^{[1
]}

Farhood, Bagher ^{[2
]}

Haghi-Aminjan, Hamed ^{[3
]}

Mortezazadeh, Tohid ^{[4
]}

Aliasgharzadeh, Akbar ^{[2
]}

Mohseni, Mehran ^{[2
]}

Najafi, Masoud ^{[5
]}

Abbasi, Hadis ^{[6
]}

机构：

[1] Univ Tehran, Fac New Sci & Technol, Dept Life Sci Engn, Tehran 1439957131, Iran

[2] Kashan Univ Med Sci, Fac Paramed Sci, Dept Med Phys & Radiol, Kashan, Iran

[3] Univ Tehran Med Sci, Dept Pharmacol & Toxicol, Fac Pharm, Tehran, Iran

[4] Univ Tehran Med Sci, Med Phys & Med Engn Dept, Fac Med, Tehran, Iran

[5] Kermanshah Univ Med Sci, Sch Paramed Sci, Radiol & Nucl Med Dept, Kermanshah, Iran

[6] Islamic Azad Univ, North Tehran Branch, Microbiol Dept, Tehran 1667914161, Iran

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2018年 / 44卷

关键词：

Gadolinium; Nanoparticle; MRI; NCT; Delivery systems; MRI CONTRAST AGENTS; TRANSPORT BLOOD SUBSTITUTES; DOPED SILICA NANOPARTICLES; POORLY SOLUBLE DRUGS; IN-VIVO; GD-DTPA; ATHEROSCLEROTIC PLAQUE; OXYGEN-TRANSPORT; UP-CONVERSION; PHYSICOCHEMICAL PROPERTIES;

D O I：

10.1016/j.jddst.2018.01.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Gadolinium (Gd) chelates have been widely used as contrast agent in magnetic resonance imaging (MRI). In addition to using MRI, they are interesting, as a radiosensitizer, in neutron capture therapy (NCT). However, the poor selective tissue labeling and localization provided by conventional molecular Gd chelates have confined success in both MRI and NCT applications. To encapsulate Gd into nanoparticulate materials can be considered as a method to overcome these limitations. In this regard, developing various carrier systems have increased the sensitivity and improving the targetability of the contrast agents. In this review article, an overview of the delivery systems of Gd nanoparticles in the MRI and NCT would be mentioned.

引用

页码：457 / 466

页数：10

共 127 条

[1] Evaluation of absorbed dose in Gadolinium neutron capture therapy [J].