Dopaminergic modulation of long-lasting direct current-induced cortical excitability changes in the human motor cortex

被引:241
作者
Nitsche, MA [1 ]
Lampe, C [1 ]
Antal, A [1 ]
Liebetanz, D [1 ]
Lang, N [1 ]
Tergau, F [1 ]
Paulus, W [1 ]
机构
[1] Univ Gottingen, Dept Clin Neurophysiol, D-37099 Gottingen, Germany
关键词
brain; cortex; dopamine; human; neuroplasticity; transcranial direct current stimulation;
D O I
10.1111/j.1460-9568.2006.04676.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Dopaminergic mechanisms participate in N-methyl-D-aspartate (NMDA) receptor-dependent neuroplasticity, as animal experiments have shown. This may be similar in humans, where dopamine influences learning and memory. We tested the role of dopamine in human cortical neuroplasticity. Changes of excitability were induced by transcranial direct current stimulation (tDCS). D2 receptor blocking by sulpiride abolished the induction of after-effects nearly completely. D1 activation alone in the presence of D2 receptor blocking induced by co-administration of sulpiride and pergolide did not re-establish the excitability changes induced by tDCS. This suggests that D2 receptors play a major supporting role in inducing neuroplasticity in the human motor cortex. Enhancement of D2 and, to a lesser degree, D1 receptors by pergolide consolidated tDCS-generated excitability diminution until the morning after stimulation. The readiest explanation for this pattern of results is that D2 receptor activation has a consolidation-enhancing effect on tDCS-induced changes of excitability in the human cortex. The results of this study underscore the importance of the dopaminergic system for human neuroplasticity, suggest a first pharmacological add-on mechanism to prolong the excitability-diminishing effects of cathodal tDCS for up to 24 h after stimulation, and thus render the application of tDCS practicable in diseases displaying enhanced cortical excitability, e.g. migraine and epilepsy.
引用
收藏
页码:1651 / 1657
页数:7
相关论文
共 51 条
  • [1] Facilitation of visuo-motor learning by transcranial direct current stimulation of the motor and extrastriate visual areas in humans
    Antal, A
    Nitsche, MA
    Kincses, TZ
    Kruse, W
    Hoffmann, KP
    Paulus, W
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2004, 19 (10) : 2888 - 2892
  • [2] Direct current stimulation over V5 enhances visuomotor coordination by improving motion perception in humans
    Antal, A
    Nitsche, MA
    Kruse, W
    Kincses, TZ
    Hoffmann, KP
    Paulus, W
    [J]. JOURNAL OF COGNITIVE NEUROSCIENCE, 2004, 16 (04) : 521 - 527
  • [3] Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway
    Bach, ME
    Barad, M
    Son, H
    Zhuo, M
    Lu, YF
    Shih, R
    Mansuy, I
    Hawkins, RD
    Kandel, ER
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (09) : 5280 - 5285
  • [4] Is heterosynaptic modulation essential for stabilizing Hebbian plasticity and memory?
    Bailey, CH
    Giustetto, M
    Huang, YY
    Hawkins, RD
    Kandel, ER
    [J]. NATURE REVIEWS NEUROSCIENCE, 2000, 1 (01) : 11 - 20
  • [5] Modulation of use-dependent plasticity by D-amphetamine
    Bütefisch, CM
    Davis, BC
    Sawaki, L
    Waldvogel, D
    Classen, J
    Kopylev, L
    Cohen, LG
    [J]. ANNALS OF NEUROLOGY, 2002, 51 (01) : 59 - 68
  • [6] CALABRESI P, 1992, J NEUROSCI, V12, P4224
  • [7] Calabresi P, 1997, J NEUROSCI, V17, P4536
  • [8] Centonze D, 2003, J NEUROSCI, V23, P6245
  • [9] Chen ZX, 1996, RECEPTOR CHANNEL, V4, P1
  • [10] Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease
    Deleu, D
    Northway, MG
    Hanssens, Y
    [J]. CLINICAL PHARMACOKINETICS, 2002, 41 (04) : 261 - 309