The Intestinal Crypt, A Prototype Stem Cell Compartment

被引：873
作者：
Clevers, Hans [1 ,2 ]
机构：
[1] Royal Netherlands Acad Arts & Sci, Hubrecht Inst, NL-3584 CT Utrecht, Netherlands
[2] Univ Med Ctr, NL-3584 CX Utrecht, Netherlands
来源：
CELL | 2013年 / 154卷 / 02期
关键词：
MOUSE SMALL INTESTINE; WNT/BETA-CATENIN; BETA-CATENIN; PANETH CELLS; PROGENITOR CELLS; SECRETORY PROGENITOR; JUVENILE POLYPOSIS; COLORECTAL-CANCER; SELF-RENEWAL; IN-VITRO;
D O I：
10.1016/j.cell.2013.07.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Due to its intense self-renewal kinetics and its simple repetitive architecture, the intestinal epithelium has become a prime model for studying adult stem cells in health and disease. Transgenic mouse models allow in vivo visualization and genetic lineage tracing of individual intestinal stem cells and their offspring. Fluorescently marked stem cells can be isolated for molecular analyses or can be cultured to build ever-expanding "mini-guts" in vitro. These studies are filling in the outlines of a robust homeostatic self-renewal process that defies some of the classical definitions of stem cell behavior, such as asymmetric division, quiescence, and exhaustion. © 2013 Elsevier Inc.
引用
收藏
页码：274 / 284
页数：11
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  • [11] Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells
    Breault, David T.
    Min, Irene M.
    Carlone, Diana L.
    Farilla, Loredana G.
    Ambruzs, Dana M.
    Henderson, Daniel E.
    Algra, Selma
    Montgomery, Robert K.
    Wagers, Amy J.
    Hole, Nicholas
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (30) : 10420 - 10425
  • [12] Intestinal label-retaining cells are secretory precursors expressing Lgr5
    Buczacki, Simon J. A.
    Zecchini, Heather Ireland
    Nicholson, Anna M.
    Russell, Roslin
    Vermeulen, Louis
    Kemp, Richard
    Winton, Douglas J.
    [J]. NATURE, 2013, 495 (7439) : 65 - 69
  • [13] MUTATION SELECTION AND NATURAL-HISTORY OF CANCER
    CAIRNS, J
    [J]. NATURE, 1975, 255 (5505) : 197 - 200
  • [14] R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling
    Carmon, Kendra S.
    Gong, Xing
    Lin, Qiushi
    Thomas, Anthony
    Liu, Qingyun
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (28) : 11452 - 11457
  • [15] ORIGIN, DIFFERENTIATION AND RENEWAL OF 4 MAIN EPITHELIAL-CELL TYPES IN MOUSE SMALL INTESTINE .5. UNITARIAN THEORY OF ORIGIN OF 4 EPITHELIAL-CELL TYPES
    CHENG, H
    LEBLOND, CP
    [J]. AMERICAN JOURNAL OF ANATOMY, 1974, 141 (04): : 537 - &
  • [16] ORIGIN, DIFFERENTIATION AND RENEWAL OF 4 MAIN EPITHELIAL-CELL TYPES IN MOUSE SMALL INTESTINE .1. COLUMNAR CELL
    CHENG, H
    LEBLOND, CP
    [J]. AMERICAN JOURNAL OF ANATOMY, 1974, 141 (04): : 461 - &
  • [17] SnapShot: The Intestinal Crypt
    Clevers, Hans
    Batlle, Eduard
    [J]. CELL, 2013, 152 (05) : 1198 - +
  • [18] Wnt/β-Catenin Signaling and Disease
    Clevers, Hans
    Nusse, Roel
    [J]. CELL, 2012, 149 (06) : 1192 - 1205
  • [19] Paneth Cells: Maestros of the Small Intestinal Crypts
    Clevers, Hans C.
    Bevins, Charles L.
    [J]. ANNUAL REVIEW OF PHYSIOLOGY, VOL 75, 2013, 75 : 289 - 311
  • [20] Peyer's Patch M Cells Derived from Lgr5+ Stem Cells Require SpiB and Are Induced by RankL in Cultured "Miniguts"
    de Lau, Wim
    Kujala, Pekka
    Schneeberger, Kerstin
    Middendorp, Sabine
    Li, Vivian S. W.
    Barker, Nick
    Martens, Anton
    Hofhuis, Frans
    DeKoter, Rodney P.
    Peters, Peter J.
    Nieuwenhuis, Edward
    Clevers, Hans
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2012, 32 (18) : 3639 - 3647
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