The Intestinal Crypt, A Prototype Stem Cell Compartment

被引：873
作者：
Clevers, Hans [1 ,2 ]
机构：
[1] Royal Netherlands Acad Arts & Sci, Hubrecht Inst, NL-3584 CT Utrecht, Netherlands
[2] Univ Med Ctr, NL-3584 CX Utrecht, Netherlands
来源：
CELL | 2013年 / 154卷 / 02期
关键词：
MOUSE SMALL INTESTINE; WNT/BETA-CATENIN; BETA-CATENIN; PANETH CELLS; PROGENITOR CELLS; SECRETORY PROGENITOR; JUVENILE POLYPOSIS; COLORECTAL-CANCER; SELF-RENEWAL; IN-VITRO;
D O I：
10.1016/j.cell.2013.07.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Due to its intense self-renewal kinetics and its simple repetitive architecture, the intestinal epithelium has become a prime model for studying adult stem cells in health and disease. Transgenic mouse models allow in vivo visualization and genetic lineage tracing of individual intestinal stem cells and their offspring. Fluorescently marked stem cells can be isolated for molecular analyses or can be cultured to build ever-expanding "mini-guts" in vitro. These studies are filling in the outlines of a robust homeostatic self-renewal process that defies some of the classical definitions of stem cell behavior, such as asymmetric division, quiescence, and exhaustion. © 2013 Elsevier Inc.
引用
收藏
页码：274 / 284
页数：11
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