Synthesis of some 4-thiazolidinones as potential antitubercular agents

被引：0

作者：

Joshi, DG ^{[1
]}

Oza, HB ^{[1
]}

Parekh, HH ^{[1
]}

机构：

[1] Saurashtra Univ, Dept Chem, Rajkot 360005, Gujarat, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2001年 / 11卷 / 02期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The starting compound 5-nitro benzimidazol-2'-yl-o-benzoyl hydrazide, on treatment with aromatic aldehydes yielded the corresponding benzal - (5'-nitrobenzimidazol-2'-yl-o-benzolyl) hydrazines (2a-o). The heterocyclisation of (2a-o) with thioglycollic acid and thiolactic acid furnished the corresponding 2-aryl-3-(5'-nitrobenzimidazol-2'-yl-o-benzamido)-5-H-4-thiazolidinones (3a-o) and 2-aryl-3-(5'-nitro benzimidazol-2'-yl-o-benzamido)-5-methyl-4-thiazolidinones (4a-o). The compounds were screened for their antitubercular activity against Mycobacterium tuberculosis H-37 Rv.

引用

页码：145 / 148

页数：4