Copper-Catalyzed Hydrodefluorination of Fluoroarenes by Copper Hydride Intermediates

被引：83

作者：

Lv, Hongbin ^{[1
]}

Cai, Yuan-Bo ^{[1
]}

Zhang, Jun-Long ^{[1
]}

机构：

[1] Peking Univ, Beijing Natl Lab Mol Sci, State Key Lab Rare Earth Mat Chem & Applicat, Coll Chem & Mol Engn, Beijing 100871, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 11期

关键词：

C-F activation; copper; fluorine; homogeneous catalysis; hydrides; C-F BOND; CARBON-FLUORINE BONDS; ACTIVATION; RHODIUM; PENTAFLUOROPYRIDINE; HEXAFLUOROPROPENE; CP-ASTERISK-2ZRH2; PERFLUOROARENES; HYDROSILYLATION; FLUOROPYRIDINES;

D O I：

10.1002/anie.201208364

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Breaking bad: Efficient copper-catalyzed C-F bond activation has been achieved by replacing fluorine with hydrogen. A copper hydride is proposed as the active intermediate, which proceeds through a nucleophilic attack on the fluorocarbon, as determined by experimental and theoretical results (see structure; C gray, H white, Cu light red, F light blue; distances in Å). © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3203 / 3207

页数：5

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