The effectiveness of radiotherapy in the treatment of head and neck mucosal melanoma: Systematic review and meta-analysis

被引：30
作者：
Grant-Freemantle, Marc C. [1 ]
Lane O'Neill, Billy [2 ]
Clover, Anthony James P. [1 ,2 ]
机构：
[1] Univ Coll Cork, Sch Med, Cork, Ireland
[2] Cork Univ Hosp, Dept Plast Surg, Cork, Ireland
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2021年 / 43卷 / 01期
关键词：
endoscopic resection; head and neck; laryngeal melanoma; mucosal melanoma; oral melanoma; radiotherapy; sinonasal melanoma; surgery; ADJUVANT RADIATION-THERAPY; MALIGNANT-MELANOMA; POSTOPERATIVE RADIOTHERAPY; NASAL CAVITY; EXPERIENCE; PROGNOSIS; SURVIVAL; OUTCOMES;
D O I：
10.1002/hed.26470
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Introduction Mucosal melanoma (MM) is a rare condition with a poor prognosis. Surgery is the corner stone of treatment, however, radiotherapy has been commonly employed as a treatment strategy and recent studies suggesting that survival outcomes may be improving are emerging. Methods A systematic review and meta-analysis comparing risk ratios of radiotherapy and surgery and radiotherapy (SRT) with surgery for 5-year overall survival, local recurrence and distant metastasis in head and neck mucosal melanoma (HNMM). Results SRT has a lower risk of death compared to surgery [RR 0.93 [95% CI = 0.87, 0.98] (P= .01)] and a reduced risk of local recurrence [RR 0.63 [95% CI = 0.48, 0.82] (P= .005)]. SRT has no effect on distant metastasis. Radiotherapy has worse survival when compared to surgery [RR 1.2 [95% CI = 1.03, 1.33] (P= .0006)]. Conclusions SRT confers a moderate survival advantage in HNMM compared to surgery. This is most likely secondary to reduced local recurrence.
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收藏
页码：323 / 333
页数：11
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