Heterobimetallic ferrocenylthiosemicarbazone palladium(II) complexes: Synthesis, electrochemistry and antiplasmodial evaluation

被引：15
|
作者：
Adams, Muneebah [1 ]
de Kock, Carmen [2 ]
Smith, Peter J. [2 ]
Malatji, Peter [1 ]
Hutton, Alan T. [1 ]
Chibale, Kelly [1 ,3 ]
Smith, Gregory S. [1 ]
机构：
[1] Univ Cape Town, Dept Chem, ZA-7701 Rondebosch, South Africa
[2] Univ Cape Town, Dept Med, Div Pharmacol, OMB,Groote Schuur Hosp, ZA-7925 Observatory, South Africa
[3] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7701 Rondebosch, South Africa
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2013年 / 739卷
基金：
新加坡国家研究基金会;
关键词：
Bioorganometallic chemistry; Thiosemicarbazone; Cyclic voltammetry; Antiplasmodial activity; IN-VITRO EVALUATION; ANTIMALARIAL ACTIVITY; PLASMODIUM-FALCIPARUM; THIOSEMICARBAZONE COMPLEXES; ORGANOMETALLIC COMPOUNDS; MOLECULAR-STRUCTURES; PLATINUM COMPLEXES; CRYSTAL-STRUCTURES; ANTICANCER DRUGS; IRON CHELATORS;
D O I：
10.1016/j.jorganchem.2013.04.017
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Heterobimetallic ferrocenylthiosemicarbazone palladium(II) complexes (3-5) were prepared through the cleavage of a chlorido-bridged palladium ferrocenylthiosemicarbazone intermediate (2) using various P-donor ligands. These compounds were screened for antiplasmodial activity against chloroquine-sensitive (NF54) and chloroquine-resistant (Dd2) Plasmodium falciparum strains, exhibiting biological activity in the low micromolar range. The compounds generally display well-resolved electrochemically reversible one-electron transfer processes for the ferrocenyl group. The half-wave potential for the Fe(II)/Fe(III) couple is electronically influenced by the type of P-donor group through the palladium(II) centre. (C) 2013 Elsevier B.V. All rights reserved.
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收藏
页码：15 / 20
页数：6
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