Activated Protein C Anticoagulant System Dysfunction and Thrombophilia in Asia

被引：22

作者：

Hamasaki, Naotaka ^{[1
]}

Kuma, Hiroyuki ^{[1
]}

Tsuda, Hiroko ^{[2
]}

机构：

[1] Nagasaki Int Univ, Fac Pharmaceut Sci, Dept Clin Chem, Nagasaki 8593298, Japan

[2] Nakamura Gakuen Univ, Dept Nutr Sci, Fukuoka, Japan

来源：

ANNALS OF LABORATORY MEDICINE | 2013年 / 33卷 / 01期

关键词：

Venous thromboembolism; Activated protein C anticoagulant system; Asian thrombophilia; Deep vein thrombosis; Protein S; Quantitative assay of protein S; DEEP-VEIN THROMBOSIS; COAGULATION-FACTOR-V; VONWILLEBRAND-FACTOR GENE; ACCEPTOR SITE MUTATION; S DEFICIENCY; VENOUS THROMBOSIS; MISSENSE MUTATIONS; HIGH PREVALENCE; NONSENSE MUTATION; CRYSTAL-STRUCTURE;

D O I：

10.3343/alm.2013.33.1.8

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Thrombophilia that is common among Caucasians is caused by genetic polymorphisms of coagulation factor V Leiden (R506Q) and prothrombin G20210A. Unlike that in Caucasians, thrombophilia that is common in the Japanese and Chinese involve dysfunction of the activated protein C (APC) anticoagulant system caused by abnormal protein S and protein C molecules. Approximately 50% of Japanese and Chinese individuals who develop venous thrombosis have reduced activities of protein S. The abnormal sites causing the protein S molecule abnormalities are distributed throughout the protein S gene, PROS1. One of the most common abnormalities is protein S Tokushima (K155E), which accounts for about 30% of the protein S molecule abnormalities in the Japanese. Whether APC dysfunction occurs in other Asian countries is an important aspect of mapping thrombophilia among Asians. International surveys using an accurate assay system are needed to determine this.

引用

页码：8 / 13

页数：6

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