Rapid Rebound of a Preexisting CXCR4-tropic Human Immunodeficiency Virus Variant After Allogeneic Transplantation With CCR5 Δ32 Homozygous Stem Cells

被引：38

作者：

Verheyen, Jens ^{[1
,2
]}

Thielen, Alexander ^{[2
]}

Luebke, Nadine ^{[3
]}

Dirks, Miriam ^{[1
]}

Widera, Marek ^{[1
]}

Dittmer, Ulf ^{[1
]}

Kordelas, Lambros ^{[4
]}

Daeumer, Martin ^{[2
]}

de Jong, Dorien C. M. ^{[5
]}

Wensing, Annemarie M. J. ^{[5
]}

Kaiser, Rolf ^{[6
]}

Nijhuis, Monique ^{[5
]}

Esser, Stefan ^{[7
]}

机构：

[1] Univ Duisburg Essen, Univ Hosp, Inst Virol, Duisburg, Germany

[2] Inst Immunol & Genet, Pfaffpl 10, D-67655 Kaiserslautern, Germany

[3] Heinrich Heine Univ, Univ Hosp, Inst Virol, Dusseldorf, Germany

[4] Univ Duisburg Essen, Univ Hosp, Dept Bone Marrow Transplantat, Duisburg, Germany

[5] Univ Med Ctr Utrecht, Dept Med Microbiol, Virol, Utrecht, Netherlands

[6] Univ Cologne, Inst Virol, Cologne, Germany

[7] Univ Duisburg Essen, Univ Hosp, Dermatol Clin, Duisburg, Germany

来源：

CLINICAL INFECTIOUS DISEASES | 2019年 / 68卷 / 04期

关键词：

HIV-1; cure; alloSCT; Delta 32 stem cells; rebound; HIV TROPISM; SHIFT;

D O I：

10.1093/cid/ciy565

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Allogeneic stem cell transplantation (alloSCT) of homozygous CCR5 Delta 32 stem cells once resulted in the cure of human immunodeficiency virus (HIV) infection. We have recently reported a viral breakthrough in a similar setting. Here, we demonstrate that the rapid rebound after alloSCT was related to a highly replicative CXCR4-tropic HIV variant, which could already be detected before alloSCT.

引用

页码：684 / 687

页数：4

共 12 条

[11] Differential modulation of CCR5-tropic human immunodeficiency virus-1 transfer from macrophages towards T cells under interleukin-4/interleukin-13 microenvironment
Saidi, Hela
Carbonneil, Cedric
Magri, Giuliana
Eslahpazir, Jobin
Sekaly, Rafick-Pierre
Belec, Laurent
HUMAN IMMUNOLOGY, 2010, 71 (01) : 1 - 13
[12] Mutations in the V3 stem versus the V3 crown and C4 region have different effects on the binding and fusion steps of human immunodeficiency virus type 1 gp120 interaction with the CCR5 coreceptor
Suphaphiphat, Pirada
Essex, Max
Lee, Tun-Hou
VIROLOGY, 2007, 360 (01) : 182 - 190

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