Rapid Rebound of a Preexisting CXCR4-tropic Human Immunodeficiency Virus Variant After Allogeneic Transplantation With CCR5 Δ32 Homozygous Stem Cells

被引：38
|
作者：
Verheyen, Jens [1 ,2 ]
Thielen, Alexander [2 ]
Luebke, Nadine [3 ]
Dirks, Miriam [1 ]
Widera, Marek [1 ]
Dittmer, Ulf [1 ]
Kordelas, Lambros [4 ]
Daeumer, Martin [2 ]
de Jong, Dorien C. M. [5 ]
Wensing, Annemarie M. J. [5 ]
Kaiser, Rolf [6 ]
Nijhuis, Monique [5 ]
Esser, Stefan [7 ]
机构：
[1] Univ Duisburg Essen, Univ Hosp, Inst Virol, Duisburg, Germany
[2] Inst Immunol & Genet, Pfaffpl 10, D-67655 Kaiserslautern, Germany
[3] Heinrich Heine Univ, Univ Hosp, Inst Virol, Dusseldorf, Germany
[4] Univ Duisburg Essen, Univ Hosp, Dept Bone Marrow Transplantat, Duisburg, Germany
[5] Univ Med Ctr Utrecht, Dept Med Microbiol, Virol, Utrecht, Netherlands
[6] Univ Cologne, Inst Virol, Cologne, Germany
[7] Univ Duisburg Essen, Univ Hosp, Dermatol Clin, Duisburg, Germany
来源：
CLINICAL INFECTIOUS DISEASES | 2019年 / 68卷 / 04期
关键词：
HIV-1; cure; alloSCT; Delta 32 stem cells; rebound; HIV TROPISM; SHIFT;
D O I：
10.1093/cid/ciy565
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Allogeneic stem cell transplantation (alloSCT) of homozygous CCR5 Delta 32 stem cells once resulted in the cure of human immunodeficiency virus (HIV) infection. We have recently reported a viral breakthrough in a similar setting. Here, we demonstrate that the rapid rebound after alloSCT was related to a highly replicative CXCR4-tropic HIV variant, which could already be detected before alloSCT.
引用
收藏
页码：684 / 687
页数：4
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