A Metal-Free Sulfenylation and Bromosulfenylation of Indoles: Controllable Synthesis of 3-Arylthioindoles and 2-Bromo-3-arylthioindoles

被引：133
作者：
Huang, Dayun [1 ]
Chen, Jiuxi [1 ]
Dan, Weixing [1 ]
Ding, Jinchang [1 ,2 ]
Liu, Miaochang [1 ]
Wu, Huayue [1 ]
机构：
[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China
[2] Wenzhou Vocat & Tech Coll, Coll Light Ind, Wenzhou 325035, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2012年 / 354卷 / 11-12期
基金：
中国国家自然科学基金;
关键词：
3-arylthioindoles; 2-bromo-3-arylthioindoles; bromosulfenylation; metal-free conditions; sulfenylation; EFFICIENT SULFENYLATION; CATALYZED SULFENYLATION; QUINONE MONO-O; S-ACETALS; POTENT INHIBITORS; 2ND SULFENYLATION; ARYL SULFONES; 3-SULFENYL; DISULFIDES; 3-SELENYLINDOLES; ARYLTHIOINDOLES;
D O I：
10.1002/adsc.201200227
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An efficient metal-free sulfenylation of indoles with disulfides has been developed, leading to 3-arylthioindoles in moderate to excellent yields. Furthermore, bromosulfenylation of indoles with disulfides has been realized for the first time providing a new family of 2-bromo-3-arylthioindole derivatives in good yield by the one-pot construction of C-S and C-Br bonds. It is noteworthy that the system enables the use of both the RS moieties in RSSR and shows a broad functional group tolerance.
引用
收藏
页码：2123 / 2128
页数：6
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