Pharmacokinetics of Maraviroc, Raltegravir, Darunavir, and Etravirine in the Semen of HIV-Infected Men

被引：12
作者：
Antoniou, Tony [1 ,2 ]
Hasan, Sumaira [3 ]
Loutfy, Mona R. [4 ,5 ,6 ]
Kovacs, Colin [5 ,7 ]
Brunetta, Jason [7 ]
Smith, Graham [7 ]
Halpenny, Roberta [7 ]
La Porte, Charles [3 ]
机构：
[1] St Michaels Hosp, Dept Family & Community Med, Toronto, ON M5B 1W8, Canada
[2] Univ Toronto, Leslie Dan Fac Pharm, Toronto, ON, Canada
[3] Ottawa Hosp, Res Inst, Ottawa, ON, Canada
[4] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada
[5] Univ Toronto, Dept Med, Toronto, ON, Canada
[6] Womens Coll Hosp, Womens Coll Res Inst, Toronto, ON M5S 1B2, Canada
[7] Maple Leaf Med Clin, Toronto, ON, Canada
来源：
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2013年 / 62卷 / 02期
关键词：
MULTIPLE-DOSE PHARMACOKINETICS; MALE GENITAL-TRACT; RECTAL TISSUE; NEGATIVE MEN; SINGLE; SANCTUARY;
D O I：
10.1097/QAI.0b013e31827a0d71
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
引用
收藏
页码：E58 / E60
页数：3
相关论文
共 16 条
[1]   The Male Genital Tract Is Not a Pharmacological Sanctuary From Efavirenz [J].
Avery, L. B. ;
Bakshi, R. P. ;
Cao, Y. J. ;
Hendrix, C. W. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2011, 90 (01) :151-156
[2]   High Concentration of Raltegravir in Semen of HIV-Infected Men: Results from a Substudy of the EASIER-ANRS 138 Trial [J].
Barau, Caroline ;
Delaugerre, Constance ;
Braun, Josephine ;
de Castro, Nathalie ;
Furlan, Valerie ;
Charreau, Isabelle ;
Gerard, Laurence ;
Lascoux-Combe, Caroline ;
Molina, Jean-Michel ;
Taburet, Anne-Marie .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (02) :937-939
[3]   Single- and Multiple-Dose Pharmacokinetics of Darunavir Plus Ritonavir and Etravirine in Semen and Rectal Tissue of HIV-Negative Men [J].
Brown, Kevin C. ;
Patterson, Kristine B. ;
Jennings, Steven H. ;
Malone, Stephanie A. ;
Shaheen, Nicholas J. ;
Prince, Heather M. Asher ;
Spacek, Melissa ;
Cohen, Myron S. ;
Kashuba, Angela D. M. .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2012, 61 (02) :138-144
[4]   Single and Multiple Dose Pharmacokinetics of Maraviroc in Saliva, Semen, and Rectal Tissue of Healthy HIV-negative Men [J].
Brown, Kevin C. ;
Patterson, Kristine B. ;
Malone, Stephanie A. ;
Shaheen, Nicholas J. ;
Prince, Heather M. Asher ;
Dumond, Julie B. ;
Spacek, Melissa B. ;
Heidt, Paris E. ;
Cohen, Myron S. ;
Kashuba, Angela D. M. .
JOURNAL OF INFECTIOUS DISEASES, 2011, 203 (10) :1484-1490
[5]   Raltegravir Penetration in Seminal Plasma of Healthy Volunteers [J].
Calcagno, Andrea ;
Bonora, Stefano ;
D'Avolio, Antonio ;
Siccardi, Marco ;
Simiele, Marco ;
Chiesa, Mattia ;
de Requena, Daniel Gonzalez ;
Di Perri, Giovanni .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (06) :2744-2745
[6]   Male genital tract pharmacology: Developments in quantitative methods to better understand a complex peripheral compartment [J].
Cao, Y-J ;
Hendrix, C. W. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2008, 83 (03) :401-412
[7]   TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates [J].
De Meyer, S ;
Azijn, H ;
Surleraux, D ;
Jochmans, D ;
Tahri, A ;
Pauwels, R ;
Wigerinck, P ;
de Béthune, MP .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (06) :2314-2321
[8]   Pharmacokinetics of once-daily etravirine without and with once-daily darunavir/ritonavir in antiretroviral-naive HIV type-1-infected adults [J].
DeJesus, Edwin ;
Lalezari, Jacob P. ;
Osiyemi, Olayemi O. ;
Ruane, Peter J. ;
Ryan, Robert ;
Kakuda, Thomas N. ;
Witek, James .
ANTIVIRAL THERAPY, 2010, 15 (05) :711-720
[9]   Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the male and female genital tract [J].
Else, Laura J. ;
Taylor, Stephen ;
Back, David J. ;
Khoo, Saye H. .
ANTIVIRAL THERAPY, 2011, 16 (08) :1149-1167
[10]  
European Medicines Agency, CELS EPAR PROD INF
12