Hereditary Colorectal Cancer: Genetics and Screening

被引：32
作者：
Brosens, Lodewijk A. A. [1 ,2 ]
Offerhaus, G. Johan A. [1 ]
Giardiello, Francis M. [3 ,4 ]
机构：
[1] Univ Med Ctr Utrecht, Dept Pathol, NL-3584 CX Utrecht, Netherlands
[2] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21231 USA
[3] Johns Hopkins Univ, Sch Med, Ctr Oncol, Dept Med, Baltimore, MD 21205 USA
[4] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA
来源：
SURGICAL CLINICS OF NORTH AMERICA | 2015年 / 95卷 / 05期
关键词：
Colorectal cancer; Hereditary nonpolyposis colorectal cancer; Lynch syndrome; Familial adenomatous polyposis; MUTYH-associated polyposis; FAMILIAL ADENOMATOUS POLYPOSIS; MUTYH-ASSOCIATED POLYPOSIS; LYNCH-SYNDROME; COLON-CANCER; MOLECULAR-FEATURES; GERMLINE MUTATIONS; RECTAL-CANCER; APC; NEOPLASIA; HNPCC;
D O I：
10.1016/j.suc.2015.05.004
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death in men and women in the United States. About 30% of patients with CRC report a family history of CRC. However, only 5% of CRCs arise in the setting of a well-established mendelian inherited disorder. In addition, serrated polyposis is a clinically defined syndrome with multiple serrated polyps in the colorectum and an increased CRC risk for which the genetics are unknown. This article focuses on genetic and clinical aspects of Lynch syndrome, familial adenomatous polyposis, and MUTYH-associated polyposis.
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收藏
页码：1067 / +
页数：16
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