Effects of cardiac resynchronization therapy on disease progression in chronic heart failure

被引:27
作者
Donal, E
Leclercq, C
Linde, C
Daubert, JC
机构
[1] Hop Pontchaillou CHU, Dept Cardiol, F-35033 Rennes 09, France
[2] Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden
关键词
cardiac resynchronization therapy; heart failure; disease progression; ventricular remodelling;
D O I
10.1093/eurheartj/ehi734
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Despite the alleviation of symptoms and longer survival conferred by pharmacological management of chronic congestive heart failure (CHF), this progressive syndrome remains associated with high morbidity and premature death. A new treatment of CHF should ideally alleviate symptoms, improve functional capacity, decrease mortality, and slow or reverse its progression without adding risks for the patient that outweighs the benefits. Growing evidence indicates that devices implanted to resynchronize ventricular contraction are a beneficial adjunct in the treatment of CHF. This review discusses the remodelling process, and its clinical and prognostic significance. We also discuss the impact of CRT, on remodelling and disease progression with a particular focus on patients with asymptomatic or mild heart failure (NYHA Class I-II).
引用
收藏
页码:1018 / 1025
页数:8
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