Ergoferon Increases IL-2 Production by Activated Lymphocytes

被引：5
|
作者：
Kanareikina, M. A. [1 ]
Alinkina, E. S. [1 ]
Petrova, A. O. [1 ]
Emel'yanova, A. G. [1 ]
Gorbunov, E. A. [1 ]
Tarasov, S. A. [2 ]
机构：
[1] Mat Med Holding Res & Prod Co, Moscow, Russia
[2] Res Inst Gen Pathol & Pathophysiol Moscow, Dept Mol & Cellular Pathophysiol, Lab Physiol Act Subst, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2019年 / 166卷 / 06期
关键词：
T cells; IL-2; released-activity; CD4; Ergoferon; INFECTION; KINASE; VIRUS; CELLS;
D O I：
10.1007/s10517-019-04431-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effects of Ergoferon on the production of antiviral cytokine IL-2 by type 1 CD4(+)T cells. Preincubation of Jurkat cells with Ergoferon increased IL-2 secretion by these cells after stimulation with phorbol 12-myristate 13-acetate/ionomycine in comparison with the placebo group. The data prove that Ergoferon is capable of activating cell cascades involved in the realization of the antiviral immune response.
引用
收藏
页码：744 / 746
页数：3
相关论文
共 50 条
  • [1] Ergoferon Increases IL-2 Production by Activated Lymphocytes
    M. A. Kanareikina
    E. S. Alinkina
    A. O. Petrova
    A. G. Emel’yanova
    E. A. Gorbunov
    S. A. Tarasov
    Bulletin of Experimental Biology and Medicine, 2019, 166 : 744 - 746
  • [2] INHIBITION OF IL-2 SECRETION AND IL-2 RECEPTOR APPEARANCE OF ACTIVATED LYMPHOCYTES PRETREATED WITH HYDROXYLATED STEROLS
    RICHERT, L
    BECK, JP
    SHINITZKY, M
    IMMUNOBIOLOGY, 1986, 173 (2-5) : 130 - 131
  • [3] INHIBITION OF IL-2 SECRETION AND IL-2 RECEPTOR APPEARANCE OF ACTIVATED LYMPHOCYTES PRETREATED WITH HYDROXYLATED STEROLS
    RICHERT, L
    BECK, JP
    SHINITZKY, M
    IMMUNOLOGY LETTERS, 1986, 13 (06) : 329 - 334
  • [4] CLINICAL USE OF IL-2 ACTIVATED TUMOR-INFILTRATING LYMPHOCYTES AND IL-2 IN THE TREATMENT OF METASTATIC CANCER
    KRADIN, R
    BOYLE, L
    GROVE, B
    MULLIN, J
    STRAUSS, W
    CALLAHAN, R
    PREFFER, F
    DUBINETT, S
    KURNICK, J
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1987, 28 : 364 - 364
  • [5] CLINICAL USE OF IL-2 ACTIVATED TUMOR-INFILTRATING LYMPHOCYTES AND IL-2 IN THE TREATMENT OF METASTATIC CANCER
    KRADIN, R
    STRAUSS, W
    KURNICK, J
    CLINICAL RESEARCH, 1987, 35 (03): : A629 - A629
  • [6] EVIDENCE FOR 2 DISCRETE PHASES OF IL-2 PRODUCTION IN BOVINE LYMPHOCYTES
    WEINBERG, AD
    MAGNUSON, NS
    REEVES, R
    WYATT, CR
    MAGNUSON, JA
    JOURNAL OF IMMUNOLOGY, 1988, 141 (04): : 1174 - 1179
  • [7] Early calcium signaling and calcium requirements for the IL-2 receptor expression and IL-2 production in stimulated lymphocytes
    Komada, H
    Nakabayashi, H
    Hara, M
    Izutsu, K
    CELLULAR IMMUNOLOGY, 1996, 173 (02) : 215 - 220
  • [8] IL-2/LAK CELL THERAPY INCREASES THE TUMORICIDAL ACTIVITY OF ALVEOLAR LYMPHOCYTES
    WENCEL, ML
    MOORE, AL
    HACKER, MP
    DAVIS, GS
    CLINICAL RESEARCH, 1990, 38 (02): : A440 - A440
  • [9] Copper deficiency reduces interleukin-2 (IL-2) production and IL-2 mRNA in human T-lymphocytes
    Hopkins, RG
    Failla, ML
    JOURNAL OF NUTRITION, 1997, 127 (02): : 257 - 262
  • [10] KINETIC-ANALYSIS OF INTERLEUKIN-2 (IL-2) PRODUCTION AND EXPRESSION OF IL-2 RECEPTORS BY UREMIC AND NORMAL LYMPHOCYTES
    LANGHOFF, E
    HOFMANN, B
    ODUM, N
    LADEFOGED, J
    PLATZ, P
    RYDER, LP
    SVEJGAARD, A
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1987, 25 (01) : 29 - 36
12345