Immune regulatory functions of DOCK family proteins in health and disease

被引：69

作者：

Nishikimi, Akihiko ^{[1
,2
,3
]}

Kukimoto-Niino, Mutsuko ^{[3
,4
]}

Yokoyama, Shigeyuki ^{[3
,4
,5
]}

Fukui, Yoshinori ^{[1
,2
,3
]}

机构：

[1] Kyushu Univ, Div Immunogenet, Dept Immunobiol & Neurosci, Med Inst Bioregulat, Fukuoka 8128582, Japan

[2] Kyushu Univ, Res Ctr Adv Immunol, Fukuoka 8128582, Japan

[3] Japan Sci & Technol Agcy, CREST, Tokyo 1020075, Japan

[4] RIKEN Syst & Struct Biol Ctr, Yokohama, Kanagawa 2300045, Japan

[5] Univ Tokyo, Grad Sch Sci, Dept Biophys & Biochem, Tokyo 1130033, Japan

来源：

EXPERIMENTAL CELL RESEARCH | 2013年 / 319卷 / 15期

基金：

日本学术振兴会; 日本科学技术振兴机构;

关键词：

Migration; Activation; Leukocytes; Small GTPases; Guanine nucleotide exchange factors; T-CELL SURVIVAL; NUCLEOTIDE EXCHANGE; RAC ACTIVATOR; ACTIN CYTOSKELETON; CDC42; ACTIVATOR; RHO-GTPASES; LYMPHOCYTE; DEDICATOR; MIGRATION; DOMAIN;

D O I：

10.1016/j.yexcr.2013.07.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DOCK proteins constitute a family of evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho family of GTPases. Although DOCK family proteins do not contain the Dbl homology domain typically found in GEFs, they mediate the GTP-GDP exchange reaction through DHR-2 domain. Accumulating evidence indicates that the DOCK proteins act as major GEFs in varied biological settings. For example, DOCK2, which is predominantly expressed in hematopoietic cells, regulates migration and activation of leukocytes through Rac activation. On the other hand, it was recently reported that mutations of DOCK8, another member of the DOCK family proteins, cause a combined immunodeficiency syndrome in humans. This article reviews the structure, functions and signaling of DOCK2 and DOCK8, especially focusing on their roles in immune responses. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：2343 / 2349

页数：7

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