Receptor selective ruthenium-somatostatin photosensitizer for cancer targeted photodynamic applications

被引：80

作者：

Wang, Tao ^{[1
]}

Zabarska, Natalia ^{[2
]}

Wu, Yuzhou ^{[1
]}

Lamla, Markus ^{[1
]}

Fischer, Stephan ^{[1
]}

Monczak, Katharina ^{[2
]}

Ng, David Y. W. ^{[1
]}

Rau, Sven ^{[2
]}

Weil, Tanja ^{[1
]}

机构：

[1] Univ Ulm, Inst Organ Chem 3, D-89081 Ulm, Germany

[2] Univ Ulm, Inst Inorgan Chem 1, D-89081 Ulm, Germany

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 63期

关键词：

RU(II) POLYPYRIDYL COMPLEXES; NATIVE DISULFIDE BONDS; SINGLET OXYGEN; THERAPY; PEGYLATION; EFFICIENT; AGENTS; CHARGE; STATES; DNA;

D O I：

10.1039/c5cc03473f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The efficient conjugation of a ruthenium complex and the peptide hormone somatostatin is presented. The resultant biohybrid offers valuable features for photodynamic therapy such as remarkable cellular selectivity, rapid cell uptake by receptor-mediated endocytosis, efficient generation of O-1(2) upon irradiation, potent photo-toxicity as well as low cytotoxicity in the "off"-state.

引用

页码：12552 / 12555

页数：4

共 45 条

[41] Singlet oxygen production in water: Aggregation and charge-transfer effects [J].