Receptor selective ruthenium-somatostatin photosensitizer for cancer targeted photodynamic applications

被引：80
作者：
Wang, Tao [1 ]
Zabarska, Natalia [2 ]
Wu, Yuzhou [1 ]
Lamla, Markus [1 ]
Fischer, Stephan [1 ]
Monczak, Katharina [2 ]
Ng, David Y. W. [1 ]
Rau, Sven [2 ]
Weil, Tanja [1 ]
机构：
[1] Univ Ulm, Inst Organ Chem 3, D-89081 Ulm, Germany
[2] Univ Ulm, Inst Inorgan Chem 1, D-89081 Ulm, Germany
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 63期
关键词：
RU(II) POLYPYRIDYL COMPLEXES; NATIVE DISULFIDE BONDS; SINGLET OXYGEN; THERAPY; PEGYLATION; EFFICIENT; AGENTS; CHARGE; STATES; DNA;
D O I：
10.1039/c5cc03473f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The efficient conjugation of a ruthenium complex and the peptide hormone somatostatin is presented. The resultant biohybrid offers valuable features for photodynamic therapy such as remarkable cellular selectivity, rapid cell uptake by receptor-mediated endocytosis, efficient generation of O-1(2) upon irradiation, potent photo-toxicity as well as low cytotoxicity in the "off"-state.
引用
收藏
页码：12552 / 12555
页数：4
相关论文
共 45 条
[1]   Mechanism of quenching by oxygen of the excited states of ruthenium(II) complexes in aqueous media.: Solvent isotope effect and photosensitized generation of singlet oxygen, O2(1Δg), by [Ru(diimine)(CN)4]2- complex ions [J].
Abdel-Shafi, Ayman A. ;
Ward, Michael D. ;
Schmidt, Reinhard .
DALTON TRANSACTIONS, 2007, (24) :2517-2527
[2]   Oncologic photodynamic therapy photosensitizers: A clinical review [J].
Allison, Ron R. ;
Sibata, Claudio H. .
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2010, 7 (02) :61-75
[3]   Site-Specific and Stoichiometric Conjugation of Cationic Porphyrins to Antiangiogenic Monoclonal Antibodies [J].
Alonso, Cristina M. A. ;
Palumbo, Alessandro ;
Bullous, Aaron J. ;
Pretto, Francesca ;
Neri, Dario ;
Boyle, Ross W. .
BIOCONJUGATE CHEMISTRY, 2010, 21 (02) :302-313
[4]   Half-Sandwich Ruthenium(II) Biotin Conjugates as Biological Vectors to Cancer Cells [J].
Babak, Maria V. ;
Plazuk, Damian ;
Meier, Samuel M. ;
Arabshahi, Homayon John ;
Reynisson, Johannes ;
Rychlik, Blazej ;
Blauz, Andrzej ;
Szulc, Katarzyna ;
Hanif, Muhammad ;
Strobl, Sebastian ;
Roller, Alexander ;
Keppler, Bernhard K. ;
Hartinger, Christian G. .
CHEMISTRY-A EUROPEAN JOURNAL, 2015, 21 (13) :5110-5117
[5]  
Balzani V., 2007, Photochemistry and Photophysics of Coordination Compounds, VI
[6]   Click Chemistry on a Ruthenium Polypyridine Complex. An Efficient and Versatile Synthetic Route for the Synthesis of Photoactive Modular Assemblies [J].
Baron, Aurelie ;
Herrero, Christian ;
Quaranta, Annamaria ;
Charlot, Marie-France ;
Leibl, Winfried ;
Vauzeilles, Boris ;
Aukauloo, Ally .
INORGANIC CHEMISTRY, 2012, 51 (11) :5985-5987
[7]   Somatostatin Subtype-2 Receptor-Targeted Metal-Based Anticancer Complexes [J].
Barragan, Flavia ;
Carrion-Salip, Dolors ;
Gomez-Pinto, Irene ;
Gonzalez-Canto, Alejandro ;
Sadler, Peter J. ;
de Llorens, Rafael ;
Moreno, Virtudes ;
Gonzalez, Carlos ;
Massaguer, Anna ;
Marchan, Vicente .
BIOCONJUGATE CHEMISTRY, 2012, 23 (09) :1838-1855
[8]   Photocontrolled DNA Binding of a Receptor-Targeted Organometallic Ruthenium(II) Complex [J].
Barragan, Flavia ;
Lopez-Senin, Paula ;
Salassa, Luca ;
Betanzos-Lara, Soledad ;
Habtemariam, Abraha ;
Moreno, Virtudes ;
Sadler, Peter J. ;
Marchan, Vicente .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (35) :14098-14108
[9]   Peptide directed transmembrane transport and nuclear localization of Ru(II) polypyridyl complexes in mammalian cells [J].
Blackmore, Lorraine ;
Moriarty, Roisin ;
Dolan, Ciaran ;
Adamson, Kellie ;
Forster, Robert J. ;
Devocelle, Marc ;
Keyes, Tia E. .
CHEMICAL COMMUNICATIONS, 2013, 49 (26) :2658-2660
[10]   An ethylene-glycol decorated ruthenium(II) complex for two-photon photodynamic therapy [J].
Boca, Sanda C. ;
Four, Mickael ;
Bonne, Adeline ;
van der Sanden, Boudewijn ;
Astilean, Simion ;
Baldeck, Patrice L. ;
Lemercier, Gilles .
CHEMICAL COMMUNICATIONS, 2009, (30) :4590-4592
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