Brain metabolism differs in Alzheimer's disease and Parkinson's disease dementia

被引：59
作者：
Griffith, H. Randall [1 ,2 ,3 ]
den Hollander, Jan A. [4 ]
Okonkwo, Ozioma C. [3 ]
O'Brien, Timothy [3 ]
Watts, Ray L. [1 ,2 ]
Marson, Daniel C. [1 ,2 ]
机构：
[1] Univ Alabama Birmingham, Dept Neurol, Birmingham, AL 35294 USA
[2] Univ Alabama Birmingham, Alzheimers Dis Res Ctr, Birmingham, AL 35294 USA
[3] Univ Alabama Birmingham, Dept Psychol, Birmingham, AL 35294 USA
[4] Univ Alabama Birmingham, Dept Med Cardiol, Birmingham, AL 35294 USA
来源：
ALZHEIMERS & DEMENTIA | 2008年 / 4卷 / 06期
关键词：
Parkinson disease; Alzheimer disease; MR spectroscopy; N-acetyl aspartate; Gyrus cinguli;
D O I：
10.1016/j.jalz.2008.04.008
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: Few comparative Studies exist of metabolic brain changes among neurodegenerative illnesses. We compared brain metabolic abnormalities in Alzheimer's disease (AD) and in Parkinson's disease with dementia (PDD) as measured by proton magnetic resonance spectroscopy (MRS). Methods: Twelve patients with idiopathic PDD, 22 patients with probable mild AD, and 61 healthy older controls underwent posterior cingulate MRS. Results: Patients with AD exhibited reduced N-acetyl aspartate (NAA)/creatine (Cr) (P <.05) and increased choline (Cho)/Cr (P < 05) and myo-inositol (ml)/Cr (P <.01) compared with controls. Patients with PDD exhibited reduced NAA/Cr (P <.05) and glutamate (Glu)/Cr (P <.01) compared with controls. There was reduced Glu/Cr in PDD compared with AD (P <.01). Conclusions: Patients with AD and patients with PDD exhibited distinct brain metabolic MRS profiles. Findings suggest that comparison of brain MRS profiles across dementias provides useful direction for future Study. (C) 2008 The Alzheimer's Association. All rights reserved.
引用
收藏
页码：421 / 427
页数：7
相关论文
共 50 条
  • [11] Motor performance differentiates individuals with Lewy body dementia, Parkinson's and Alzheimer's disease
    Fritz, Nora E.
    Kegelmeyer, Deborah A.
    Kloos, Anne D.
    Linder, Shannon
    Park, Ariane
    Kataki, Maria
    Adeli, Anahita
    Agrawal, Punit
    Scharre, Douglas W.
    Kostyk, Sandra K.
    GAIT & POSTURE, 2016, 50 : 1 - 7
  • [12] A neurologist's view of Alzheimer's disease and dementia
    Katzman, R
    INTERNATIONAL PSYCHOGERIATRICS, 2004, 16 (03) : 259 - 273
  • [13] Alzheimer's disease and Alzheimer's dementia: distinct but overlapping entities
    Blass, JP
    NEUROBIOLOGY OF AGING, 2002, 23 (06) : 1077 - 1084
  • [14] Obstructive sleep apnea and the risk of Alzheimer's disease and Parkinson disease: A Mendelian randomization study OSA Alzheimer's disease and Parkinson disease ,
    Li, Jinwei
    Zhao, Lanqing
    Ding, Xiaoxu
    Cui, Xiangguo
    Qi, Li
    Chen, Yu
    SLEEP MEDICINE, 2022, 97 : 55 - 63
  • [15] Inflammation in mild cognitive impairment due to Parkinson's disease, Lewy body disease, and Alzheimer's disease
    King, Eleanor
    O'Brien, John
    Donaghy, Paul
    Williams-Gray, Caroline H.
    Lawson, Rachael A.
    Morris, Christopher M.
    Barnett, Nicola
    Olsen, Kirsty
    Martin-Ruiz, Carmen
    Burn, David
    Yarnall, Alison J.
    Taylor, John-Paul
    Duncan, Gordan
    Khoo, Tien K.
    Thomas, Alan
    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2019, 34 (08) : 1244 - 1250
  • [16] Caregiver Burden in Parkinson Disease With Dementia Compared to Alzheimer Disease in Korea
    Shin, Hyeeun
    Youn, Jinyoung
    Kim, Ji Sun
    Lee, Jun-Young
    Cho, Jin Whan
    JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, 2012, 25 (04) : 222 - 226
  • [17] The influence of cerebrovascular disease in dementia with Lewy bodies and Parkinson's disease dementia
    Hijazi, Zina
    Yassi, Nawaf
    O'Brien, John T.
    Watson, Rosie
    EUROPEAN JOURNAL OF NEUROLOGY, 2022, 29 (04) : 1254 - 1265
  • [18] Brain lipid metabolism, apolipoprotein E and the pathophysiology of Alzheimer's disease
    Bales, Kelly R.
    NEUROPHARMACOLOGY, 2010, 59 (4-5) : 295 - 302
  • [19] Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease
    Xu, Yunqi
    Yan, Junqiang
    Zhou, Peng
    Li, Jiejie
    Gao, Huimin
    Xia, Ying
    Wang, Qing
    PROGRESS IN NEUROBIOLOGY, 2012, 97 (01) : 1 - 13
  • [20] Familial Coaggregation of Alzheimer's Disease and Parkinson's Disease: Systematic Review and Meta-Analysis
    Feldman, Adina L.
    Johansson, Anna L. V.
    Lambert, Paul C.
    Sieurin, Johanna
    Yang, Fei
    Pedersen, Nancy L.
    Wirdefeldt, Karin
    NEUROEPIDEMIOLOGY, 2014, 42 (02) : 69 - 80
12345