Synthesis and Bioactivity of Furoxan-Based Nitric Oxide-Releasing Colchicine Derivatives as Anticancer Agents

被引：4

作者：

Shen, Li Hong ^{[1
]}

Wang, Sheng Li ^{[1
]}

Li, Hong Yu ^{[1
]}

Lai, Yi Sheng ^{[2
]}

Liu, Li Jie ^{[3
]}

机构：

[1] Handan Coll, Handan Key Lab Organ Small Mol Mat, Handan 056005, Peoples R China

[2] China Pharmaceut Univ, Ctr Drug Discovery, Nanjing 210009, Jiangsu, Peoples R China

[3] Hebei Yiling Med Corp Ltd, Shijiazhuang 050035, Peoples R China

来源：

ASIAN JOURNAL OF CHEMISTRY | 2013年 / 25卷 / 06期

关键词：

Nitric oxide-donating colchicine derivatives; N-Methyl colchiceinamide; Furoxan; Cytotoxicity; BIOLOGICAL EVALUATION; DESIGN; ANALOGS;

D O I：

10.14233/ajchem.2013.13635

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel nitric oxide-donating colchicine derivatives (9a-j) were synthesized by coupling furoxan with N-methyl colchiceinamide through an appropriate space arm and their cytotoxicity against four human cancer cell lines in vitro were evaluated by MTT method. It was found that many of the derivatives displayed significant activity, particularly, compound 9f showed more potent cytotoxic activities than colchicine.

引用

页码：3294 / 3296

页数：3

共 15 条

[1] Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin [J].

Bhattacharyya, Bhabatarak ;

Panda, Dulal ;

Gupta, Suvroma ;

Banerjee, Mithu .

MEDICINAL RESEARCH REVIEWS, 2008, 28 (01) :155-183

[2]

Cerquaglia C., 2005, Current Drug Targets - Inflammation and Allergy, V4, P117

[3] Design, synthesis and identification of novel colchicine-derived immunosuppressant [J].

Chang, Dong-Jo ;

Yoon, Eun-Young ;

Lee, Geon-Bong ;

Kim, Soon-Ok ;

Kim, Wan-Joo ;

Kim, Young-Myeong ;

Jung, Jong-Wha ;

An, Hongchan ;

Suh, Young-Ger .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (15) :4416-4420

[4] Synthesis and biological evaluation of B-ring modified colchicine and isocolchicine analogs [J].

Cifuentes, M ;

Schilling, B ;

Ravindra, R ;

Winter, J ;

Janik, ME .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (10) :2761-2764

[5] Design and synthesis of furoxan-based nitric oxide-releasing glucocorticoid derivatives with potent anti-inflammatory activity and improved safety [J].

Fang, Lei ;

Zhang, Yihua ;

Lehmann, Jochen ;

Wang, You ;

Ji, Hui ;

Ding, Dayong .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (04) :1062-1066

[6] Natural inhibitors of carcinogenesis [J].

Kinghorn, AD ;

Su, BN ;

Jang, DS ;

Chang, LC ;

Lee, D ;

Gu, JQ ;

Carcache-Blanco, EJ ;

Powlus, AD ;

Lee, SK ;

Park, EJ ;

Cuendet, M ;

Gills, JJ ;

Bhat, K ;

Park, HS ;

Mata-Greenwood, E ;

Song, LL ;

Jong, MH ;

Pezzuto, JM .

PLANTA MEDICA, 2004, 70 (08) :691-705

[7] Current developments in the discovery and design of new drug candidates from plant natural product leads [J].

Lee, KH .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (02) :273-283

[8] Novel furoxan NO-donor pemetrexed derivatives: design, synthesis, and preliminary biological evaluation [J].

Min, Tao ;

Yi, Bixin ;

Zhang, Peng ;

Liu, Jun ;

Zhang, Can ;

Zhou, Huiping .

MEDICINAL CHEMISTRY RESEARCH, 2009, 18 (07) :495-510

[9] Nitric Oxide: Cancer Target or Anticancer Agent? [J].

Mocellin, Simone .

CURRENT CANCER DRUG TARGETS, 2009, 9 (02) :214-236

[10] Colchicine today [J].

Niel, Elisabeth ;

Scherrmann, Jean-Michel .

JOINT BONE SPINE, 2006, 73 (06) :672-678

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