Anticonvulsant properties of the selective 5-HT6 receptor antagonist SB-271046 in the rat maximal electroshock seizure threshold test

被引：0

作者：

Stean, T ^{[1
]}

Routledge, C ^{[1
]}

Upton, N ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Neurosci Res, Harlow CM19 5AW, Essex, England

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1999年 / 127卷

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

131P

引用

页码：U71 / U71

页数：1

共 4 条

[1] 5-chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046):: A potent, selective, and orally bioavailable 5-HT6 receptor antagonist [J].

Bromidge, SM ;

Brown, AM ;

Clarke, SE ;

Dodgson, K ;

Gager, T ;

Grassam, HL ;

Jeffrey, PM ;

Joiner, GF ;

King, FD ;

Middlemiss, DN ;

Moss, SF ;

Newman, H ;

Riley, G ;

Routledge, C ;

Wyman, P .

JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (02) :202-205

[2]

LITCHFIELD JT, 1949, J PHARMACOL EXP THER, V96, P99

[3] Studies on the role of 5-HT2C and 5-HT2B receptors in regulating generalised seizure threshold in rodents [J].

Upton, N ;

Stean, T ;

Middlemiss, D ;

Blackburn, T ;

Kennett, G .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 359 (01) :33-40

[4] Profile of SB-204269, a mechanistically novel anticonvulsant drug, in rat models of focal and generalized epileptic seizures [J].

Upton, N ;

Blackburn, TP ;

Campbell, CA ;

Cooper, D ;

Evans, ML ;

Herdon, HJ ;

King, PD ;

Ray, AM ;

Stean, TO ;

Chan, WN ;

Evans, JM ;

Thompson, M .

BRITISH JOURNAL OF PHARMACOLOGY, 1997, 121 (08) :1679-1686

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