Effects of phenytoin on cortical excitability in humans

被引：182

作者：

Chen, R ^{[1
]}

Samii, A ^{[1
]}

Canos, M ^{[1
]}

Wassermann, EM ^{[1
]}

Hallett, M ^{[1
]}

机构：

[1] NINCDS,HUMAN MOTOR CONTROL SECT,MED NEUROL BRANCH,NIH,BETHESDA,MD 20892

来源：

NEUROLOGY | 1997年 / 49卷 / 03期

关键词：

D O I：

10.1212/WNL.49.3.881

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied the effects of a loading dose of phenytoin on motor cortex excitability in five healthy volunteers. Phenytoin elevated motor thresholds to transcranial magnetic stimulation (TMS) in all subjects, but had no effects on motor-evoked potential amplitudes, silent period durations, and intracortical excitability tested by paired TMS during rest and voluntary muscle activation. These results are consistent with the hypothesis that blockade of voltage-gated sodium channels decreases membrane excitability and elevates the threshold to TMS, but will not reduce intracortical excitability.

引用

页码：881 / 883

页数：3

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