Gut microbiota as a promising therapeutic target for age-related sarcopenia

被引：45
|
作者：
Zhang, Ting [1 ]
Cheng, Jin-ke [2 ]
Hu, Yao-min [1 ,3 ]
机构：
[1] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Geriatr, Shanghai 200127, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp Affiliated, Dept Biochem & Mol Cell Biol,State Key Lab Oncogen, Shanghai 200025, Peoples R China
[3] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Geriatr, 160 Pujian Rd, Shanghai 200127, Peoples R China
来源：
AGEING RESEARCH REVIEWS | 2022年 / 81卷
关键词：
Sarcopenia; Aging; Gut microbiota; Skeletal muscle; Probiotics; Microbiota; SKELETAL-MUSCLE; MITOCHONDRIAL-FUNCTION; ANABOLIC RESISTANCE; EXERCISE; ATROPHY; INFLAMMATION; EXPRESSION; IMPACTS; CANCER;
D O I：
10.1016/j.arr.2022.101739
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Sarcopenia is characterized by a progressive loss of skeletal muscle mass and function with aging. Recently, sarcopenia has been shown to be closely related with gut microbiota. Strategies such as probiotics and fecal microbiota transplantation have shown potential to ameliorate the muscle loss. This review will focus on the age -related sarcopenia, in particular on the relationship between gut microbiota and age-related sarcopenia, how gut microbiota is engaged in sarcopenia, and the potential role of gut microbiota in the treatment of age-related sarcopenia.
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页数：12
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