B2pin2-Mediated Cascade Cyclization/Aromatization Reaction: Facial Access to Functionalized Indolizines

被引：33

作者：

Li, Xiaoning ^{[1
]}

Chen, Zunsheng ^{[2
]}

Chen, Weiming ^{[2
]}

Xie, Xin ^{[2
]}

Zhou, Hui ^{[2
]}

Liao, Yingmei ^{[2
]}

Yu, Fuchao ^{[3
]}

Huang, Jiuzhong ^{[1
]}

机构：

[1] Gannan Med Univ, Minist Educ, Sch Pharm, Key Lab Prevent & Treatment Cardiovasc Dis, Ganzhou, Peoples R China

[2] Gannan Med Univ, Sch Pharm, Ganzhou 341000, Peoples R China

[3] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 40期

基金：

中国国家自然科学基金;

关键词：

B BOND FORMATION; RADICAL BORYLATION; HYDROBORATION; DERIVATIVES; CATALYSIS;

D O I：

10.1021/acs.orglett.2c02905

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, a B2pin2-mediated radical cascade cyclization/aromatization reaction of enaminone with pyridine is described. This strategy provides a practical way for the construction of valuable functionalized indolizines under metal-, external oxidant-, and base-free conditions, which could be compatible with various kinds of functional groups, such as halogen, pi-system, heterocycle, ferrocenyl, etc. A preliminary mechanism investigation indicated that the pyridine-boryl radical formed in situ triggered the reaction to occur.

引用

页码：7372 / 7377

页数：6

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