The effect of enterovirus 71 immunization on neuropathogenesis and protein expression profiles in the thalamus of infected rhesus neonates

被引：25

作者：

Chen, Huicheng ^{[1
,2
,3
]}

Zhang, Ying ^{[1
,2
]}

Yang, Erxia ^{[1
,2
]}

Liu, Longding ^{[1
,2
]}

Che, Yanchun ^{[1
,2
]}

Wang, Jingjing ^{[1
,2
]}

Zhao, Hongling ^{[1
,2
]}

Tang, Donghong ^{[1
,2
]}

Dong, Chenghong ^{[1
,2
]}

Yang, Lixian ^{[1
,2
]}

Shen, Dong ^{[1
,2
]}

Wang, Xi ^{[1
,2
]}

Liao, Yun ^{[1
,2
]}

Wang, Lichun ^{[1
,2
]}

Na, Ruixiong ^{[1
,2
]}

Liang, Yan ^{[1
,2
]}

Li, Qihan ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Biol, Kunming 650118, Yunnan, Peoples R China

[2] Peking Union Med Coll, Yunnan Key Lab Vaccine Res & Dev Severe Infect Di, Kunming 650118, Yunnan, Peoples R China

[3] Yunnan Univ, Sch Life Sci, Kunming 650091, Peoples R China

来源：

VIROLOGY | 2012年 / 432卷 / 02期

关键词：

Enterovirus 71 (EV71); Expression profiles; Inactivated virus vaccines; Neuropathogenesis; Neonatal rhesus monkeys; Thalamus; CENTRAL-NERVOUS-SYSTEM; ANTIBODY-DEPENDENT ENHANCEMENT; BRAIN-STEM ENCEPHALITIS; PARKINSONS-DISEASE; MOUTH-DISEASE; PULMONARY-EDEMA; IN-VITRO; TAIWAN; OUTBREAK; ENCEPHALOMYELITIS;

D O I：

10.1016/j.virol.2012.06.026

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Enterovirus 71 (EV71) is a major pathogen that causes hand-foot-mouth disease (HEMD). Our previous studies have demonstrated that the complete process of pathogenesis, which may include tissue damage induced by host inflammatory responses and direct tissue damage caused by viral infection, can be observed in the central nervous system (CNS) of animals infected in the laboratory with EV71. Based on these observations, the neuropathogenesis and protein expression profiles in the thalamic tissues of EV71-infected animals were further analyzed in the present study. Changes in protein expression profiles following immunization with the inactivated EV71 vaccine followed by virus challenge were observed and evaluated, and their physiological roles in viral pathogenesis are discussed. Taken together, the results of these experiments provide evidence regarding the neuropathogenesis and molecular mechanisms associated with EV71 infection and identify several protein indicators of pathogenic changes during viral infection. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.

引用

页码：417 / 426

页数：10

共 46 条

[31] Survival after pulmonary edema due to enterovirus 71 encephalitis [J].