Biomimetic monolayer-protected gold nanoparticles for immunorecognition

被引：20

作者：

Harkness, Kellen M. ^{[1
]}

Turner, Brian N. ^{[1
]}

Agrawal, Amanda C. ^{[1
]}

Zhang, Yibin ^{[1
]}

McLean, John A. ^{[1
]}

Cliffel, David E. ^{[1
]}

机构：

[1] Vanderbilt Univ, Vanderbilt Inst Integrat Biosyst Res & Educ, Vanderbilt Inst Chem Biol, Dept Chem,Stevenson Ctr 7330,Stn B 351822, Nashville, TN 37235 USA

来源：

NANOSCALE | 2012年 / 4卷 / 13期

基金：

美国国家卫生研究院;

关键词：

SURFACE-PLASMON RESONANCE; MASS-SPECTROMETRY; JANUS NANOPARTICLES; CRYSTAL BIOSENSOR; CLUSTER MOLECULES; LIGAND; GLUTATHIONE; TIOPRONIN; EXCHANGE; EPITOPE;

D O I：

10.1039/c2nr30467h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gold nanoparticles (AuNPs) protected by self-assembled monolayers (SAMs) are capable of presenting precisely engineered surfaces at the nanoscale, allowing the mimicry of biomacromolecules on an artificial platform. Here we review the generation, characterization, and applications of monolayer-protected AuNPs that have been designed for immunorecognition by the integration of an oligopeptide epitope into the protecting monolayer. The resulting peptide-AuNP conjugate is an effective platform for biomimesis, as demonstrated by multiple studies. Recent work is presented and future directions for this field of research are discussed.

引用

页码：3843 / 3851

页数：9

共 84 条

[11] Synthesis of mixed monolayer-protected gold clusters from thiol mixtures: Variation in the tail group, chain length, and solvent
Choo, H
Cutler, E
Shon, YS
[J]. LANGMUIR, 2003, 19 (20) : 8555 - 8559
[12] Gold nanostructures: a class of multifunctional materials for biomedical applications
Cobley, Claire M.
Chen, Jingyi
Cho, Eun Chul
Wang, Lihong V.
Xia, Younan
[J]. CHEMICAL SOCIETY REVIEWS, 2011, 40 (01) : 44 - 56
[13] Nanoparticle MALDI-TOF mass spectrometry without fragmentation:: Au25(SCH2CH2Ph)18 and mixed monolayer Au25(SCH2CH2Ph)18-x(L)x
Dass, Amala
Stevenson, Anthony
Dubay, George R.
Tracy, Joseph B.
Murray, Royce W.
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (18) : 5940 - 5946
[14] Faradaurate Nanomolecules: A Superstable Plasmonic 76.3 kDa Cluster
Dass, Amala
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (48) : 19259 - 19261
[15] Mass Spectrometrically Detected Statistical Aspects of Ligand Populations in Mixed Monolayer Au25L18 Nanoparticles
Dass, Amala
Holt, Kennedy
Parker, Joseph F.
Feldberg, Stephen W.
Murray, Royce W.
[J]. JOURNAL OF PHYSICAL CHEMISTRY C, 2008, 112 (51) : 20276 - 20283
[16] CONTINUOUS LIQUID-PHASE PIEZOELECTRIC BIOSENSOR FOR KINETIC IMMUNOASSAYS
DAVIS, KA
LEARY, TR
[J]. ANALYTICAL CHEMISTRY, 1989, 61 (11) : 1227 - 1230
[17] ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA) QUANTITATIVE ASSAY OF IMMUNOGLOBULIN-G
ENGVALL, E
PERLMANN, P
[J]. IMMUNOCHEMISTRY, 1971, 8 (09): : 871 - &
[18] Epitope mapping of the protective antigen of B-anthracis by using nanoclusters presenting conformational peptide epitopes
Gerdon, AE
Wright, DW
Cliffel, DE
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (04) : 594 - 598
[19] Hemagglutinin linear epitope presentation on monolayer-protected clusters elicits strong antibody binding
Gerdon, AE
Wright, DW
Cliffel, DE
[J]. BIOMACROMOLECULES, 2005, 6 (06) : 3419 - 3424
[20] Quartz crystal microbalance detection of glutathione-protected nanoclusters using antibody recognition
Gerdon, AE
Wright, DW
Cliffel, DE
[J]. ANALYTICAL CHEMISTRY, 2005, 77 (01) : 304 - 310

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