Biomimetic monolayer-protected gold nanoparticles for immunorecognition

被引：20

作者：

Harkness, Kellen M. ^{[1
]}

Turner, Brian N. ^{[1
]}

Agrawal, Amanda C. ^{[1
]}

Zhang, Yibin ^{[1
]}

McLean, John A. ^{[1
]}

Cliffel, David E. ^{[1
]}

机构：

[1] Vanderbilt Univ, Vanderbilt Inst Integrat Biosyst Res & Educ, Vanderbilt Inst Chem Biol, Dept Chem,Stevenson Ctr 7330,Stn B 351822, Nashville, TN 37235 USA

来源：

NANOSCALE | 2012年 / 4卷 / 13期

基金：

美国国家卫生研究院;

关键词：

SURFACE-PLASMON RESONANCE; MASS-SPECTROMETRY; JANUS NANOPARTICLES; CRYSTAL BIOSENSOR; CLUSTER MOLECULES; LIGAND; GLUTATHIONE; TIOPRONIN; EXCHANGE; EPITOPE;

D O I：

10.1039/c2nr30467h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gold nanoparticles (AuNPs) protected by self-assembled monolayers (SAMs) are capable of presenting precisely engineered surfaces at the nanoscale, allowing the mimicry of biomacromolecules on an artificial platform. Here we review the generation, characterization, and applications of monolayer-protected AuNPs that have been designed for immunorecognition by the integration of an oligopeptide epitope into the protecting monolayer. The resulting peptide-AuNP conjugate is an effective platform for biomimesis, as demonstrated by multiple studies. Recent work is presented and future directions for this field of research are discussed.

引用

页码：3843 / 3851

页数：9

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