Active surveillance versus nonradical treatment for low-risk men with prostate cancer: a review

被引：4

作者：

Perera, Sachin ^{[1
,4
]}

McDonald, Jodie ^{[1
,2
,3
]}

Williams, Isabella ^{[1
]}

O'Brien, Jonathan ^{[2
,3
]}

Murphy, Declan ^{[2
,3
]}

Lawrentschuk, Nathan ^{[1
,4
]}

机构：

[1] Univ Melbourne, Dept Urol, Royal Melbourne Hosp, Melbourne, Vic, Australia

[2] Univ Melbourne, Royal Melbourne Hosp, Dept Surg, Melbourne, Vic, Australia

[3] Peter MacCallum Canc Ctr, Div Canc Surg, Melbourne, Vic, Australia

[4] EJ Whitten Fdn Prostate Canc Res Ctr Epworth, Melbourne, Vic, Australia

来源：

PROSTATE INTERNATIONAL | 2022年 / 10卷 / 03期

关键词：

Active surveillance; low risk; nonradical treatment; progression; prostate cancer; survival; DUTASTERIDE; CARE;

D O I：

10.1016/j.prnil.2022.08.002

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Low-risk prostate cancer has traditionally seen a preference towards avoiding treatment-related harms with active surveillance (AS) and multimodal monitoring protocols utilized to assess for disease progression. Large trials have shown variations in mortality and cancer survival benefit between AS and radical treatment, which has prompted further trials into the management of low-risk disease. Non-radical treatments for men on AS have been an emerging field and yet to enter mainstream guidelines or practice. These include pharmacological treatments, focal therapy, nutraceuticals, immunotherapy, and exercise. We present a review of all current major randomized clinical trials for nonradical treatment of men on AS and summarize their findings. (C) 2022 Asian Pacific Prostate Society. Publishing services by Elsevier B.V.

引用

页码：117 / 122

页数：6

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