The adaptive immune response to colorectal cancer: From the laboratory to clinical practice

被引：17
作者：
Curtis, N. J. [1 ,2 ]
Primrose, J. N. [1 ,2 ]
Thomas, G. J. [1 ,3 ]
Mirnezami, A. H. [1 ,2 ]
Ottensmeier, C. H. [1 ]
机构：
[1] Univ Southampton, Canc Sci Div, Southampton Gen Hosp, Southampton SO16 6YD, Hants, England
[2] Southampton Univ Hosp, Dept Surg, Southampton SO16 6YD, Hants, England
[3] Southampton Univ Hosp, Dept Cellular Pathol, Southampton SO16 6YD, Hants, England
来源：
EJSO | 2012年 / 38卷 / 10期
关键词：
Colorectal cancer; Lymphocytes; Adaptive immune system; Prognosis; Risk stratification; REGULATORY T-CELLS; TUMOR-INFILTRATING LYMPHOCYTES; INVASIVE MARGIN; SURVIVAL; PROGNOSIS; DENSITY; INFLAMMATION; METASTASIS; TH1;
D O I：
10.1016/j.ejso.2012.05.011
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Introduction: Analysis of the adaptive immune system in the microenvironment of colorectal cancer is suggested to offer new insights into tumour biology and prognostic information independent of TNM staging. We aimed to review recent findings to investigate the potential for clinical use. Methods: Relevant papers were identified through online searches regarding tumour infiltrating lymphocytes (TIL) in colorectal cancer. Identified papers were studied, focusing on clinically applicable uses for TIL data in the management of colorectal cancer. Findings: The majority of identified studies were retrospective and observational in nature. The widest TIL investigation was in post resection prognosis but TIL subtypes, counts and methodology showed variability between studies. Recent reports explored TIL in predicting response to adjuvant and neoadjuvant treatments. Conclusion: An increasing body of evidence supports that visibility of colorectal cancer to immune attack is substantial and that it limits disease progression. Analysis of the adaptive immune infiltrate in resected colorectal cancer specimens offers prognostic information which is independent of conventionally measured parameters and potentially superior in predictive value. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：889 / 896
页数：8
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