Efficient angiogenesis-based wound healing through hydrogel dressing with extracellular vesicles release

被引：28

作者：

Han, Zhengzhe ^{[1
,2
]}

Dong, Lanlan ^{[3
]}

Li, Ang ^{[1
,2
]}

Li, Zongyue ^{[4
]}

Fu, Landie ^{[5
]}

Zhang, Zhichang ^{[1
,2
]}

Li, Xiang ^{[3
]}

Li, Xiaolin ^{[1
,2
]}

机构：

[1] Shanghai Sixth Peoples Hosp, Dept Orthoped Surg, 600 Yishan Rd, Shanghai 200233, Peoples R China

[2] Shanghai Sixth Peoples Hosp, Shanghai Inst Microsurg Extrem, 600 Yishan Rd, Shanghai 200233, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Mech Engn, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

[4] Fudan Univ, Zhongshan Hosp, Dept Rehabil Med, 180 Fenglin Rd, Shanghai, Peoples R China

[5] North Cross Sch Shanghai, Bldg 2,Lane 803,Shuangcheng Rd, Shanghai, Peoples R China

来源：

MATERIALS TODAY BIO | 2022年 / 16卷

基金：

中国国家自然科学基金;

关键词：

A; Hydrogel; B; Strength; C; Extracellular vesicles; D; Wound healing dressing; ANTIBACTERIAL; COMPOSITE;

D O I：

10.1016/j.mtbio.2022.100427

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Wound healing and angiogenesis remain challenges for both clinical and experimental research worldwide. Periosteum-derived extracellular vesicles (P-sEVs) delivered by hydrogel dressings provide a potential strategy for wound defects to promote fast healing. In this study, we designed a NAGA/GelMA/Laponite/glycerol hydrogel wound dressing that can release P-sEVs to accelerate angiogenesis and wound healing (named P-sEVs@hydrogel) (N-acryloyl glycinamide, NAGA). The wound dressing showed multiple functions, including efficient angiogen-esis, tissue adhesion and a physical barrier. P-sEVs significantly enhanced the proliferation, migration, and tube formation of endothelial cells in vitro. The results of in vivo experiments showed that P-sEVs@hydrogel accelerates the healing of a full-thickness defect wound model by stimulating the angiogenic process. The improved cell proliferation, tissue formation, remodeling, and re-epithelialization possibly resulted in the fast healing. This study shows that multifunctional hydrogel dressing combined with bioactive molecules can achieve fast and satisfactory wound healing in full-thickness wound defects and other related wounds.

引用

页数：9

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