(Gd,Yb,Tb)PO4 up-conversion nanocrystals for bimodal luminescence-MR imaging

被引：48

作者：

Debasu, Mengistie L. ^{[1
,2
]}

Ananias, Duarte ^{[2
]}

Pinho, Sonia L. C. ^{[6
]}

Geraldes, Carlos F. G. C. ^{[3
,4
,5
]}

Carlos, Luis D. ^{[1
]}

Rocha, Joao ^{[2
]}

机构：

[1] Univ Aveiro, CICECO, Dept Phys, P-3810193 Aveiro, Portugal

[2] Univ Aveiro, CICECO, Dept Chem, P-3810193 Aveiro, Portugal

[3] Univ Coimbra, Fac Sci & Technol, Dept Life Sci, P-3001401 Coimbra, Portugal

[4] Univ Coimbra, Ctr Neurosci & Cell Biol, P-3004517 Coimbra, Portugal

[5] Univ Coimbra, Ctr Quim Coimbra, P-3004535 Coimbra, Portugal

[6] INEB Inst Engn Biomed, P-4150180 Oporto, Portugal

来源：

NANOSCALE | 2012年 / 4卷 / 16期

关键词：

COOPERATIVE ENERGY-TRANSFER; CONTRAST AGENTS; YB3+; TB3+; NANOPARTICLES; EMISSION; BLUE; IONS; CRYSTALLIZATION; PARTICLES;

D O I：

10.1039/c2nr31226c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Up-conversion (Gd,Yb,Tb)PO4 materials and their potential for bimodal imaging have received little attention in the literature. Herein, we report the first study on the up-conversion emission of (Gd,Yb,Tb)PO4 nanocrystals synthesized via a hydrothermal method at 150 degrees C. These materials exhibit ultraviolet, blue and green up-conversion emissions upon excitation with a 980 nm continuous wave laser diode. The intensity of the blue-emission band at 479 nm, ascribed to the cooperative up-conversion emission of a pair of excited Yb3+ ions, depends on the Yb3+/Tb3+ concentration ratio, calcination temperature and particle size. Strong green up-conversion emission of Tb3+ is observed at 543 nm for the D-5(4) -> F-7(5) transition. Relaxometry measurements reveal that the nanocrystals are efficient T-2-weighted (negative) contrast agents which, combined with visible-light emission generated by infrared excitation, affords them considerable potential for being used in bimodal, photoluminescence-magnetic resonance, imaging.

引用

页码：5154 / 5162

页数：9

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