The hematopoietic stem cell niche: from embryo to adult

被引：161
作者：
Gao, Xin [1 ,2 ]
Xu, Chunliang [1 ,2 ]
Asada, Noboru [1 ,2 ]
Frenette, Paul S. [1 ,2 ]
机构：
[1] Albert Einstein Coll Med, Ruth L & David S Gottesman Inst Stem Cell & Regen, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Dept Med & Cell Biol, Bronx, NY 10461 USA
来源：
DEVELOPMENT | 2018年 / 145卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Bone marrow; Hematopoietic stem cell; Hemogenic endothelium; Microenvironment; Niche; BONE-MARROW NICHE; ENDOTHELIAL-CELLS; SELF-RENEWAL; YOLK-SAC; HEPATIC PROGENITORS; OSTEOBLASTIC CELLS; AORTIC ENDOTHELIUM; HSC QUIESCENCE; STROMAL CELLS; GROWTH-FACTOR;
D O I：
10.1242/dev.139691
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and finally to the bone marrow, where most HSCs reside throughout adult life. These niches provide supportive microenvironments that specify, expand and maintain HSCs. Understanding the constituents and molecular regulation of HSC niches is of considerable importance as it could shed new light on the mechanistic principles of HSC emergence and maintenance, and provide novel strategies for regenerative medicine. However, controversy exists concerning the cellular complexity of the bone marrow niche, and our understanding of the different HSC niches during development remains limited. In this Review, we summarize and discuss what is known about the heterogeneity of the HSC niches at distinct stages of their ontogeny, from the embryo to the adult bone marrow, drawing predominantly on data from mouse studies.
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页数：12
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