Ran GTPase protein promotes human pancreatic cancer proliferation by deregulating the expression of Survivin and cell cycle proteins

被引：29

作者：

Deng, Lin ^{[1
,2
]}

Lu, Yuanyuan ^{[1
]}

Zhao, Xiaodi ^{[1
]}

Sun, Yi ^{[1
]}

Shi, Yongquan ^{[1
]}

Fan, Hongwei ^{[1
]}

Liu, Changhao ^{[1
]}

Zhou, Jinfeng ^{[1
]}

Nie, Yongzhan ^{[1
]}

Wu, Kaichun ^{[1
]}

Fan, Daiming ^{[1
]}

Guo, Xuegang ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp Digest Dis, State Key Lab Canc Biol, Xian 710032, Shaanxi, Peoples R China

[2] Fourth Mil Med Univ, Tangdu Hosp, Dept Oncol, Xian 710038, Shaanxi, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2013年 / 440卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Ran; Proliferation; Pancreatic cancer; Cell cycle; Survivin; MITOTIC SPINDLE; NUCLEAR TRANSPORT; APOPTOSIS; MITOSIS; EXPORT; INHIBITION; TRANSITION; RCC1;

D O I：

10.1016/j.bbrc.2013.09.079

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ran, a member of the Ras GTPase family, has important roles in nucleocytoplasmic transport. Herein, we detected Ran expression in pancreatic cancer and explored its potential role on tumour progression. Overexpressed Ran in pancreatic cancer tissues was found highly correlated with the histological grade. Downregulation of Ran led to significant suppression of cell proliferation, cell cycle arrest at the G1/S phase and induction of apoptosis. In vivo studies also validated that result. Further studies revealed that those effects were at least partly mediated by the downregulation of Cyclin A, Cyclin D1, Cyclin E, CDK2, CDK4, phospho-Rb and Survivin proteins and up regulation of cleaved Caspase-3. Crown Copyright (C) 2013 Published by Elsevier Inc. All rights reserved.

引用

页码：322 / 329

页数：8

共 37 条

[1] High expression of Ran GTPase is associated with local invasion and metastasis of human clear cell renal cell carcinoma [J].