Monometallic complexes of 1,4,7,10-tetraazacyclododecane containing an imidazolium side: Synthesis, characterization, and their interaction with plasmid DNA

被引：80
作者：
Li, Qiang-Lin
Huang, Jun
Wang, Qin
Jiang, Ning
Xia, Chuan-Qin
Lin, Hong-Hui
Wu, Jiang
Yu, Xiao-Qi
机构：
[1] Sichuan Univ, Dept Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Sichuan, Peoples R China
[2] Sichuan Univ, Coll Life Sci, Chengdu 610064, Sichuan, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 12期
基金：
中国国家自然科学基金;
关键词：
1,4,7,10-tetraazacyclododecane (cyclen); macrocyclic polyamine; monometallic complex; imidazolium salt; synthesis; pUC19; DNA; cleavage;
D O I：
10.1016/j.bmc.2006.01.069
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of macrocyclic polyamine monometallic complexes containing imidazolium salt groups was reported. Their interaction with pUC19 plasmid DNA was studied. The result showed that these complexes can catalyze the DNA cleavage with unprecedented reactivity under physiological conditions. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4151 / 4157
页数：7
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