Antifungal Activity of a Library of Cyclitols and Related Compounds

被引：0

作者：

Bellomo, Ana ^{[1
]}

Bertucci, Ana ^{[2
]}

de la Sovera, Victoria ^{[2
]}

Carrau, Gonzalo ^{[2
]}

Raimondi, Marcela ^{[3
]}

Zacchino, Susana ^{[3
]}

Stefani, Helio A. ^{[4
]}

Gonzalez, David ^{[2
]}

机构：

[1] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, Penn Merck Lab High Throughput Experimentat, Philadelphia, PA 19104 USA

[2] Univ Republica, Fac Quim, Dept Quim Organ, UdelaR, Montevideo 1157, Uruguay

[3] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, RA-2000 Rosario, Santa Fe, Argentina

[4] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Sao Paulo, Brazil

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2014年 / 11卷 / 01期

关键词：

Inositols; Conduritols; Chemoenzymatic; Antifungal activity; Bioautography; Amino acid conjugates; CHEMOENZYMATIC SYNTHESIS; BIOCATALYSIS; CONDURITOLS; EPIDEMIOLOGY; PHOSPHATES; MYCOSES;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The antifungal activity of a library of 32 cyclitols and derivatives, including 6 previously unreported cyclitol amino acid conjugates, was studied against the clinically important yeasts Candida albicans, Candida tropicalis and Cryptococcus neoformans along with Saccharomyces cerevisiae. Bioautography followed by standardized microbroth dilution methods were used and allowed to identify an azidoinositol glycoside (11) and an azidoconduritol linked to an aromatic aldehyde (18) as promising compounds. The results suggest the relevance of exploring synthetic cyclitolic structures as potential antifungal leaders.

引用

页码：67 / 75

页数：9

共 33 条

[1]

[Anonymous], 2008, Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts

[2]

Third Informational Supplement. CLSI document M27-S3, P28

[3] CONDURITOLS AND RELATED-COMPOUNDS [J].