Assessment of cytotoxicity and toxicity for phosphonium-based deep eutectic solvents

被引：222

作者：

Hayyan, Maan ^{[1
,2
]}

Hashim, Mohd Ali ^{[2
]}

Al-Saadi, Mohammed A. ^{[2
]}

Hayyan, Adeeb ^{[2
]}

AlNashef, Inas M. ^{[3
]}

Mirghani, Mohamed E. S. ^{[4
]}

机构：

[1] Univ Malaya, Fac Engn, Dept Civil Engn, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Dept Chem Engn, Univ Malaya Ctr Ion Liquids UMCiL, Kuala Lumpur 50603, Malaysia

[3] King Saud Univ, Dept Chem Engn, Riyadh 11421, Saudi Arabia

[4] Int Islamic Univ Malaysia, Dept Biotechnol Engn, Kuala Lumpur 50728, Malaysia

来源：

CHEMOSPHERE | 2013年 / 93卷 / 02期

关键词：

Deep eutectic solvent; Ionic liquid; Cytotoxicity; Toxicity; Anti-bacteria; Brine shrimp; CHOLINE CHLORIDE; BEHAVIOR;

D O I：

10.1016/j.chemosphere.2013.05.013

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

In this work, the cytotoxicity and toxicity of phosphonium-based deep eutectic solvents (DESs) with three hydrogen bond donors, namely glycerine, ethylene glycol, and triethylene glycol were investigated. The cytotoxicity effect was tested using brine shrimp (Artemia sauna). The toxicity was investigated using the two Gram positive bacteria Bacillus subtilis and Staphylococcus aureus, and two Gram negative bacteria Escherichia coli and Pseudomonas aeruginosa. The cytotoxicity of tested DESs was much higher than that of their individual components, indicating their toxicological behavior was different. It was also found that there was toxic effect on the studied bacteria, indicating their potential application as anti-bacterial agents. To the best of our knowledge, this is the first time the cytotoxicity and toxicity of phosphonium-based DESs were studied. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：455 / 459

页数：5

共 26 条

[1] Electrodeposition of zinc-tin alloys from deep eutectic solvents based on choline chloride [J].