MRI relaxation properties of water-soluble apoferritin-encapsulated gadolinium oxide-hydroxide nanoparticles

被引：46

作者：

Sanchez, Purificacion ^{[1
]}

Valero, Elsa ^{[1
]}

Galvez, Natividad ^{[1
]}

Dominguez-Vera, Jose M. ^{[1
]}

Marinone, Massimo ^{[2
,4
]}

Poletti, Giulio ^{[2
,4
]}

Corti, Maurizio ^{[3
,4
]}

Lascialfari, Alessandro ^{[2
,3
,4
]}

机构：

[1] Univ Granada, Fac Ciencias, Dept Quim Inorgan, E-18071 Granada, Spain

[2] Univ Milan, Ist Fisiol Gen & Chim Biol G Esposito, I-20134 Milan, Italy

[3] Univ Pavia, Dipartimento Fis A Volta, I-27100 Pavia, Italy

[4] S3 CNR INFM, I-41100 Modena, Italy

来源：

DALTON TRANSACTIONS | 2009年 / 05期

关键词：

CONTRAST AGENTS; IRON STORAGE; FERRITIN; RELAXIVITY; SIZE; GADONANOTUBES; COMPLEXES; DIAGNOSIS; CAVITY; ROUTE;

D O I：

10.1039/b809645g

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We have prepared water-soluble gadolinium oxide nanoparticles that show potential as MRI contrast agents. The particles were built into the apoferritin cavity and have an average size of 5 nm. After seven days a loss of 5% of Gd was detected compared with the as-prepared samples; after that the Gd remained constant and stabilized inside the apoferritin, indicating that the apoferritin capsid acts as a Gd store, avoiding metal delivery and consequent toxicity. The NMR longitudinal and transverse relaxivities resulted about 10 and 70 times higher than the ones of clinically approved paramagnetic Gd-chelates, thus indicating the possible route for synthesizing a novel class of MRI contrast agents.

引用

页码：800 / 804

页数：5

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