RETRACTED: Immune memory responses to HBV vaccine 13-18 years after primary vaccination (Retracted Article)

被引：3

作者：

Hou, L. ^{[1
]}

Li, W. ^{[1
]}

Wei, X. ^{[2
]}

Zhou, Y. ^{[2
]}

Zhuo, Y. ^{[2
]}

Wu, H. ^{[1
]}

Shen, B. ^{[1
]}

机构：

[1] Xinxiang Med Univ, Dept Infect Dis 1, Affiliated Hosp 1, Weihui, Henan Province, Peoples R China

[2] Xinxiang Med Univ, Dept Infect Dis 2, Affiliated Hosp 1, Weihui, Henan Province, Peoples R China

来源：

GENETICS AND MOLECULAR RESEARCH | 2015年 / 14卷 / 03期

关键词：

Hepatitis B virus (HBV); Vaccine; Immune memory; HEPATITIS-B SEROPREVALENCE; LIVED PLASMA-CELLS; IMMUNOLOGICAL MEMORY; SOUTHERN BRAZIL; ANTIBODY; ANTIGEN; AVIDITY; IMMUNIZATION; ADOLESCENTS; MARKER;

D O I：

10.4238/2015.July.28.14

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this study was to evaluate the immune memory response 13-18 years after an hepatitis B virus (HBV) vaccine by performing a specific in vitro stimulation experiment. Thirty healthy volunteers who had been inoculated 13-18 years ago with the HBV vaccine were collected from the physical examination center. Peripheral blood mononuclear cells were stimulated with 50 ng/mL recombinant HBsAg. An ELISA kit was used for the detection of antibodies that were produced by these cells in vitro. It was found that even 13-18 years after inoculation with the HBV vaccine, an anamnestic antibody response still existed, and was not correlated with the serum antibody levels (r = -0.177, P = 0.377). In conclusion, our data showed that the individuals after inoculation, including those with anti-HBs <10 IU/L as well as those individuals in whom the antibody was not detected, retained immune memory, which may be the main role of memory B cells.

引用

页码：8466 / 8472

页数：7