Scaffold diversity of natural products: inspiration for combinatorial library design

被引：166
作者：
Grabowski, Kristina [1 ]
Baringhaus, Karl-Heinz [2 ]
Schneider, Gisbert [1 ]
机构：
[1] Goethe Univ Frankfurt, Inst Inorgan Chem & Chem Biol, ZAFES CMP, D-60323 Frankfurt, Germany
[2] Sanofi Aventis Deutschland GmbH, D-65926 Frankfurt, Germany
来源：
NATURAL PRODUCT REPORTS | 2008年 / 25卷 / 05期
关键词：
D O I：
10.1039/b715668p
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Natural products contain scaffold structures that can be systematically exploited for the design of combinatorial compound libraries with druglike properties. We review approaches for scaffold identification, and compare properties and pharmacophoric features of drugs and natural products. In particular, an application of the self-organizing map technique is presented for natural product-derived compound and library design.
引用
收藏
页码：892 / 904
页数：13
相关论文
共 110 条
[1]   Modern methods to produce natural-product libraries [J].
Abel, U ;
Koch, C ;
Speitling, M ;
Hansske, FG .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (04) :453-458
[2]  
[Anonymous], DICT NATURAL PRODUCT
[3]   Exploring new chemical space by stereocontrolled diversity-oriented synthesis [J].
Arya, P ;
Joseph, R ;
Gan, ZH ;
Rakic, B .
CHEMISTRY & BIOLOGY, 2005, 12 (02) :163-180
[4]   Stereoselective diversity-oriented solution and solid-phase synthesis of tetrahydroquinoline-based polycyclic derivatives [J].
Arya, P ;
Durieux, P ;
Chen, ZX ;
Joseph, R ;
Leek, DM .
JOURNAL OF COMBINATORIAL CHEMISTRY, 2004, 6 (01) :54-64
[5]  
Bajorath J., 2002, Curr. Drug Discov., V3, P24
[6]   Design of compound libraries based on natural product scaffolds and protein structure similarity clustering (PSSC) [J].
Balamurugan, R ;
Dekker, FJ ;
Waldmann, H .
MOLECULAR BIOSYSTEMS, 2005, 1 (01) :36-45
[7]   From natural products to clinically useful antifungals [J].
Barrett, D .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2002, 1587 (2-3) :224-233
[8]   Carbohydrate-based scaffolds in drug discovery [J].
Becker, Bernd ;
Condie, Glenn C. ;
Le, Giang Thanh ;
Meutermans, Wirn .
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2006, 6 (12) :1299-1309
[9]   The properties of known drugs .1. Molecular frameworks [J].
Bemis, GW ;
Murcko, MA .
JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (15) :2887-2893
[10]   Libraries from natural product-like scaffolds [J].
Boldi, AM .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2004, 8 (03) :281-286
12345678910